Mal-PEG4-Glu(TFP ester)-NH-m-PEG24 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Boc-Pip-butyn is an Alkyl/ether-based PROTAC linker[1].
E3 ligase Ligand 2 is a Ligand for E3 Ligase used in PROTAC technology.
Thalidomide-O-C8-Boc is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-O-C8-Boc can be connected to the ligand for protein by a linker to form PROTACs[1].
Biotin-PEG12-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
TCO4-PEG3-Maleimide is a PROTAC linker and belongs to the PEG class. TCO4-PEG3-Maleimide contains TCO and Maleimide groups, which can undergo specific "click" reactions with tetrazine groups or thiol groups, or "mercapto-acrylamide" reactions.
NH2-PEG1-CH2CH2-Boc is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs[1].
H-Hyp-OMe hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). H-Hyp-OMe hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]<
m-PEG4-phosphonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
N-(PEG2-Boc)-N-bis(PEG2-propargyl) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Ald-Ph-PEG4-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Azido-PEG12-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
m-PEG2-Amino is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
HO-PEG8-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Fmoc-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Benzyl-PEG7-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Propargyl-PEG3-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
N-Boc-N-bis(PEG3-NHS ester) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Acid-C2-PEG4-C2-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Mal-PEG2-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTAC BRD9 Degrader-1 is a lead PROTAC BRD9 chemical degrader, which can be used as a selective probe useful for the study of BAF complex biology[1].
PROTAC Linker 30 is a PROTAC linker, which refers to the alkyl/ether composition. PROTAC Linker 30 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
N-(Propargyl-PEG2)-N-Boc-PEG3-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
m-PEG5-Hydrazide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PEG5-bis-(Ethyl phosphonate) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTAC ERα Degrader-4 is a highly potent and selectivePROTAC ERα degrader (Ki: 5.08 μM). PROTAC ERα Degrader-4 contains OBHSAs, linker and E3 ligase ligands. PROTAC ERα Degrader-4 shows excellent cell inhibitory and ERα degradation activity against Tamoxifen-sensitive and -resistant ER+ breast cancer (BC) cells and ERα-mutated BC cells. PROTAC ERα Degrader-4 can induce apoptosis and can be used for cancer research.
Thiol-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Glucocorticoid receptor agonist-1 phosphate Ala-Ala-Br is an ADC linker that can be used as a reaction reagent for the synthesis of anti-CD40 antibody agent conjugates (ADCs)[1].
Pomalidomid-C6-PEG3-butyl-N3 is a click chemistry reagent containing an azide group. Pomalidomid-C6-PEG3-butyl-N3 also is a crosslinker-E3 ligase ligand conjugate, which be used in click reactive protein degrader building block for PROTAC research.Pomalidomid-C6-PEG3-butyl-N3 also can be used in the template for synthesis of targeted protein degrader[1].
Hydroxy-PEG6-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].