Fmoc-PEG4-NHS ester

Modify Date: 2022-08-25 10:17:21

Fmoc-PEG4-NHS ester Structure
Fmoc-PEG4-NHS ester structure
Common Name Fmoc-PEG4-NHS ester
CAS Number 1314378-14-7 Molecular Weight 584.614
Density 1.3±0.1 g/cm3 Boiling Point N/A
Molecular Formula C30H36N2O10 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Fmoc-PEG4-NHS ester


Fmoc-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 9H-Fluoren-9-ylmethyl {15-[(2,5-dioxo-1-pyrrolidinyl)oxy]-15-oxo-3,6,9,12-tetraoxapentadec-1-yl}carbamate
Synonym More Synonyms

 Fmoc-PEG4-NHS ester Biological Activity

Description Fmoc-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Molecular Formula C30H36N2O10
Molecular Weight 584.614
Exact Mass 584.237000
LogP 0.78
Index of Refraction 1.590
Storage condition -20°C

 Safety Information

Hazard Codes Xi

 Synonyms

Carbamic acid, N-[15-[(2,5-dioxo-1-pyrrolidinyl)oxy]-15-oxo-3,6,9,12-tetraoxapentadec-1-yl]-, 9H-fluoren-9-ylmethyl ester
9H-Fluoren-9-ylmethyl {15-[(2,5-dioxo-1-pyrrolidinyl)oxy]-15-oxo-3,6,9,12-tetraoxapentadec-1-yl}carbamate
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