858126-78-0

858126-78-0 structure

Name: DNP-PEG4-NHS ester
Chemical Name: 2,5-Pyrrolidinedione, 1-[3-[2-[2-[2-[2-[(2,4-dinitrophenyl)amino]ethoxy]ethoxy]ethoxy]ethoxy]-1-oxopropoxy]
CAS Number: 858126-78-0
Molecular Formula: C₂₁H₂₈N₄O₁₂
Molecular Weight: 528.46700
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2017-01-09 02:59:16
Modify Date: 2025-08-25 14:49:22
DNP-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	2,5-Pyrrolidinedione, 1-[3-[2-[2-[2-[2-[(2,4-dinitrophenyl)amino]ethoxy]ethoxy]ethoxy]ethoxy]-1-oxopropoxy]
Synonyms	dnp-nh-peg(4)-nhs 1-(2,4-dinitrophenylamino)-3,6,9,12-tetraoxapentadecanoic acid succinimidyl ester

Description	DNP-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562