DNP-PEG4-NHS ester

Modify Date: 2025-08-25 14:49:22

DNP-PEG4-NHS ester Structure
DNP-PEG4-NHS ester structure
Common Name DNP-PEG4-NHS ester
CAS Number 858126-78-0 Molecular Weight 528.46700
Density N/A Boiling Point N/A
Molecular Formula C21H28N4O12 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of DNP-PEG4-NHS ester


DNP-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 2,5-Pyrrolidinedione, 1-[3-[2-[2-[2-[2-[(2,4-dinitrophenyl)amino]ethoxy]ethoxy]ethoxy]ethoxy]-1-oxopropoxy]
Synonym More Synonyms

 DNP-PEG4-NHS ester Biological Activity

Description DNP-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Molecular Formula C21H28N4O12
Molecular Weight 528.46700
Exact Mass 528.17000
PSA 204.27000
LogP 2.03590

 Synonyms

dnp-nh-peg(4)-nhs 1-(2,4-dinitrophenylamino)-3,6,9,12-tetraoxapentadecanoic acid succinimidyl ester
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