Biotin-PEG4-NHS ester

Modify Date: 2024-01-10 21:52:12

Biotin-PEG4-NHS ester structure	Common Name	Biotin-PEG4-NHS ester
	CAS Number	459426-22-3	Molecular Weight	588.671
	Density	1.3±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₂₅H₄₀N₄O₁₀S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Biotin-PEG4-NHS ester

Biotin-PEG4-NHS ester is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	N-{15-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-15-oxo-3,6,9,12-tetraoxapentadec-1-yl}-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide
Synonym	More Synonyms

Description	Biotin-PEG4-NHS ester is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521.

1H-Thieno[3,4-d]imidazole-4-pentanamide, N-[15-[(2,5-dioxo-1-pyrrolidinyl)oxy]-15-oxo-3,6,9,12-tetraoxapentadec-1-yl]hexahydro-2-oxo-, (3aS,4S,6aR)-

N-{15-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-15-oxo-3,6,9,12-tetraoxapentadec-1-yl}-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide

MFCD08458915

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