<Suppliers Price>

Biotin-PEG4-NHS ester

Names

[ CAS No. ]:
459426-22-3

[ Name ]:
Biotin-PEG4-NHS ester

[Synonym ]:
1H-Thieno[3,4-d]imidazole-4-pentanamide, N-[15-[(2,5-dioxo-1-pyrrolidinyl)oxy]-15-oxo-3,6,9,12-tetraoxapentadec-1-yl]hexahydro-2-oxo-, (3aS,4S,6aR)-
N-{15-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-15-oxo-3,6,9,12-tetraoxapentadec-1-yl}-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide
MFCD08458915

Biological Activity

[Description]:

Biotin-PEG4-NHS ester is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Molecular Formula ]:
C25H40N4O10S

[ Molecular Weight ]:
588.671

[ Exact Mass ]:
588.246521

[ LogP ]:
-3.28

[ Index of Refraction ]:
1.566

[ Storage condition ]:
2-8°C

Related Compounds