2521299-80-7

2521299-80-7 structure

Name: PROTAC ERα Degrader-4
Chemical Name: PROTAC ERα Degrader-4
CAS Number: 2521299-80-7
Molecular Formula: C₅₅H₆₂F₃N₅O₁₀S₂
Molecular Weight: 1074.23
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2023-09-19 10:58:48
Modify Date: 2024-01-29 14:32:06
PROTAC ERα Degrader-4 is a highly potent and selectivePROTAC ERα degrader (Ki: 5.08 μM). PROTAC ERα Degrader-4 contains OBHSAs, linker and E3 ligase ligands. PROTAC ERα Degrader-4 shows excellent cell inhibitory and ERα degradation activity against Tamoxifen-sensitive and -resistant ER+ breast cancer (BC) cells and ERα-mutated BC cells. PROTAC ERα Degrader-4 can induce apoptosis and can be used for cancer research.

Name	PROTAC ERα Degrader-4

Description	PROTAC ERα Degrader-4 is a highly potent and selectivePROTAC ERα degrader (Ki: 5.08 μM). PROTAC ERα Degrader-4 contains OBHSAs, linker and E3 ligase ligands. PROTAC ERα Degrader-4 shows excellent cell inhibitory and ERα degradation activity against Tamoxifen-sensitive and -resistant ER+ breast cancer (BC) cells and ERα-mutated BC cells. PROTAC ERα Degrader-4 can induce apoptosis and can be used for cancer research.
Related Catalog	Signaling Pathways >> Others >> Estrogen Receptor/ERR Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC
Target	ERα:5.08 μM (Ki) ERβ:26.20 μM (Ki)
References	[1]. Xie B, et.al. Discovery of a Novel Class of PROTACs as Potent and Selective Estrogen Receptor α Degraders to Overcome Endocrine-Resistant Breast Cancer In Vitro and In Vivo. J Med Chem. 2023 May 25;66(10):6631-6651.

Molecular Formula	C₅₅H₆₂F₃N₅O₁₀S₂
Molecular Weight	1074.23