Avitinib (AC0010) is an irreversible, mutant-selective EGFR inhibitor that effectively inhibits EGFR T790M resistance mutations in non-small cell lung cancer (NSCLC). Abivertinib is also a novel BTK inhibitor.
Abiesadine F is a diterpenoid isolated from Abies georgei Orr[1].
H-L-Ile-Amc (TFA) is an enzyme substrate, and can detect the yeasts and molds in the sample using aminopeptidase substrates[1].
C13-113-tetra tail is a cationic lipid-like compound containing a polar amino alcohol head group, four hydrophobic carbon-13 tails, and a tertiary amine linker. C13-113-tetra tail can be formulated into a lipid nanoparticle (LNP).
JHW007 hydrochloride is the hydrochloride of JHW007. JHW007 is an antagonist of cocaine[1].
Methyl indole-3-carboxylate is a natural product isolated from Sorangium cellulosum strain Soce895. Methyl indole-3-carboxylate shows a weak activity against the Gram-positive Nocardia sp with a MIC value of 33.33 μg/mL[1].
Protocatechualdehyde (Catechaldehyde), a natural polyphenol compound isolated from the roots of radix Salviae Miltiorrhizae, is associated with a wide variety of biological activities and has been widely used in medicine as an antioxidant, anti-aging, an antibacterial and anti-inflammatory agent[1].
Fmoc-N-amido-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
YTX-465 (YTX465) is a specific small molecule that rescues yeast from a-Syn cytotoxicity with EC50 of 15 nM, via inhibiting Ole1, the yeast homolog of human stearoyl-CoA desaturase (SCD); YTX-465 is inactive at SCD1.
HBV-IN-16 is a potent inhibitor of covalently closed circular DNA (cccDNA). cccDNA serves as the template for viral RNA transcription and subsequent viral DNA generation. HBV-IN-16 is a quinoline derivative. HBV-IN-16 has the potential for the research of HBV infection (extracted from patent WO2019121357A1, compound 1)[1].
O-propargyl-puromycin, an alkyne analog of puromycin, is a potent protein synthesis inhibitor.
Idraparinux (sodium) is a polymethylated synthetic pentasaccharide known to interact with the antithrombin III and act as anticoagulant.
Catalpin is an iridoid that can be isoalted from Catalpae Fructus.Catalpin shows mutagenic activity towards Salmonella typhimurium strain TA100[1].
Interiotherin A is a lignan with a dibenzocyclooctadiene skeleton isolated from Kadsura interior. Interiotherin A inhibits HIV replication to exhibit anti-HIV activity, it has a role as a metabolite and an anti-HIV agent[1].
Vincosamide, an alkaloid from Psychotria leiocarpa extract, inhibits the acetylcholinesterase (AChE) activity with anti-inflammatory activity[1].
CDK2-IN-3 (compound 3) is a potent and selective CDK2 inhibitor with an 50 of 60 nM[1].
Jacobine N-oxide, an N-oxide of Jacobine which is a pyrrolizidine alkaloid, can be found in Senecio hybrids that has thrips resistance[1].
RGH-560 (compound 53) shows highly advanced α7 nAChR positive modulator properties and favorable physicochemical features. RGH-560 has robust procognitive in vivo potential. RGH-560 can be used to study Scopolamine (HY-N0296) -induced amnesia in mice[1].
Gatipotuzumab (PankoMab) is a humanized monoclonal antibody which recognizes the tumor-specific epitope of mucin-1 (TA-MUC1). Gatipotuzumab reveals a potent tumor-specific antibody-dependent cell cytotoxicity (ADCC)[1][2].
Cyantraniliprole(HGW-86) is an insecticide of the ryanoid class; has activity against pests such as Diaphorina citri that have developed resistance to other classes insecticides.
2-(Chloromethyl)-4-(4-nitrophenyl)thiazole (Compound APS) has anti-cancer activity in hepatocellular carcinoma (HCC) by repression of M2 polarization of Tumor-associated macrophages (TAMs). 2-(Chloromethyl)-4-(4-nitrophenyl)thiazole can be isolated from Astragalus propinquus Schischk[1].
(Rac)-3-Aminoisobutyric acid-d3 (hydrochloride) is the deuterium labeled DL-Histidine[1].
Propargyl-PEG2-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Efanesoctocog alfa (BIVV001) is a humanized CPCA antibody[1].
(S,R)-WT IDH1 Inhibitor 2 (GSK321) is a potent, selective mutant IDH1 inhibitor with IC50 values of 2.9, 3.8, 4.6 and 46 nM for R132G, R132C, R132H and WT IDH1, respectively, and >100-fold selectivity over IDH2. (S,R)-WT IDH1 Inhibitor 2 induces decrease in intracellular 2-HG, abrogation of the myeloid differentiation block and induction of granulocytic differentiation at the level of leukemic blasts and more immature stem-like cells. (S,R)-WT IDH1 Inhibitor 2 can be used for research of acute myeloid leukemia (AML) and other cancers[1].
Kushenol A is isolated from the root of Sophora flavescent, a non-competitive tyrosinase inhibitor with IC50 and Ki values of 1.1 μM and 0.4 μM, respectively[1].Kushenol A is a flavonoid antioxidant, has inhibitory effects on alpha-glucosidase and beta-amylase[2].Kushenol A is confirmed as potential inhibitors of enzymes targeted by cosmetics for skin whitening and aging[1].
DosatiLink-2 is an Abelson murine leukemia (ABL) enzyme inhibitor[1].
BI-2865 is a none-covalent pan-KRAS Inhibitor. BI-2865 binds to WT, G12C, G12D, G12V and G13D mutant KRAS with KDs of 6.9, 4.5, 32, 26, 4.3 nM respectively. BI-2865 inhibits the proliferation of G12C, G12D or G12V mutant KRAS expressing BaF3 cells (mean IC50: roughly 140 nM)[1].
Tarasaponin IV, as an oleanane-type triterpene saponin, is isolated from the bark of Aralia elata. Tarasaponin IV can be used for the research of cancer[1].
ATP-γ-S tetrasodium, an ATP analogue, is a P2Y11 receptor agonist. ATP-γ-S tetrasodium is active in ATP hydrolysis. ATP-γ-S tetrasodium is also an antioxidant and neuroprotectant[1][2].