3,4-Dihydroxybenzaldehyde

Modify Date: 2024-01-02 16:10:50

3,4-Dihydroxybenzaldehyde structure	Common Name	3,4-Dihydroxybenzaldehyde
	CAS Number	139-85-5	Molecular Weight	138.12
	Density	1.4±0.1 g/cm3	Boiling Point	295.4±20.0 °C at 760 mmHg
	Molecular Formula	C₇H₆O₃	Melting Point	150-157 °C(lit.)
	MSDS	Chinese USA	Flash Point	146.7±18.3 °C
	Symbol	GHS07	Signal Word	Warning

Use of 3,4-Dihydroxybenzaldehyde

Protocatechualdehyde (Catechaldehyde), a natural polyphenol compound isolated from the roots of radix Salviae Miltiorrhizae, is associated with a wide variety of biological activities and has been widely used in medicine as an antioxidant, anti-aging, an antibacterial and anti-inflammatory agent[1].

Name	3,4-dihydroxybenzaldehyde
Synonym	More Synonyms

Description	Protocatechualdehyde (Catechaldehyde), a natural polyphenol compound isolated from the roots of radix Salviae Miltiorrhizae, is associated with a wide variety of biological activities and has been widely used in medicine as an antioxidant, anti-aging, an antibacterial and anti-inflammatory agent[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Others >> Others
In Vitro	Protocatechualdehyde (PCA) (50, 100 μM, 24/48 hours ) treated MCF-7 cells significantly decrease cell growth by 11% and 20% in 24 hours and by 22% and 27% in 48 hours, respectively[2]. Protocatechualdehyde (50, 100 μM, 24 hours) treated MCF-7 cells are increased by 1.9-fold and 2.6-fold in the concentrations of 50 μM and 100 μM, respectively. PCA suppresses proliferation of estrogen receptor (ER)-positive (MCF-7) breast cancer cells, but not ER-negative (MDA-MB-231) breast cancer cells[2]. Protocatechualdehyde (0, 100, 200 μM, 48 hours in HCT116 and SW480 cells) affects the enzyme activity of HDAC and observed that PCA treatment resulted in inhibition of HDAC activity in dose-dependent manner[3]. Cell Proliferation Assay[2] Cell Line: Human breast cancer cell (MCF-7 and MDA-MB-231) Concentration: 0, 5, 10, 25, 50, and 100 μM Incubation Time: 24, 48 hours Result: inhibited MCF-7 cells cell growth. Apoptosis Analysis[2] Cell Line: Human breast cancer cell (MCF-7 and MDA-MB-231) Concentration: 0, 5, 10, 25, 50, and 100 μM Incubation Time: 24, 48 hours Result: increased apoptosis in MCF-7 cells.
References	[1]. Li S, et al. Evaluation of the Antibacterial Effects and Mechanism of Action of Protocatechualdehyde against Ralstonia solanacearum. Molecules. 2016 Jun 9;21(6). [2]. Choi J, et al. Anticancer activity of protocatechualdehyde in human breast cancer cells. J Med Food. 2014 Aug;17(8):842-8. [3]. Jeong JB, et al. Protocatechualdehyde possesses anti-cancer activity through downregulating cyclin D1 and HDAC2 in human colorectal cancer cells. Biochem Biophys Res Commun. 2013 Jan 4;430(1):381-6.

Density	1.4±0.1 g/cm3
Boiling Point	295.4±20.0 °C at 760 mmHg
Melting Point	150-157 °C(lit.)
Molecular Formula	C₇H₆O₃
Molecular Weight	138.12
Flash Point	146.7±18.3 °C
Exact Mass	138.031693
PSA	57.53000
LogP	1.14
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.674
Storage condition	2-8°C
Stability	Stable. Incompatible with strong bases, strong oxidizing agents.
Water Solubility	50 g/L (20 ºC)

3,4-Dihydroxybenzaldehyde MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UL0380000

CHEMICAL NAME :: Protocatechualdehyde

CAS REGISTRY NUMBER :: 139-85-5

LAST UPDATED :: 198311

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C7-H6-O3

MOLECULAR WEIGHT :: 138.13

WISWESSER LINE NOTATION :: VHR CQ DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 205 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 15,461,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#07875

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant
Risk Phrases	R36/37/38
Safety Phrases	S26-S36-S37/39
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	UL0380000
HS Code	29124900

Precursor 9
CAS#:621-59-0 Isovanillin CAS#:121-33-5 Vanillin CAS#:120-57-0 piperonal CAS#:859451-00-6 DL-3,4-dihydrox...
CAS#:869277-74-7 isatinsulfonic acid CAS#:869224-41-9 sodium isatin-s... CAS#:775-01-9 3,4-Dihydroxyma... CAS#:4383-06-6 5-(Hydroxymethy...
CAS#:120-80-9 1,2-Benzenediol
DownStream 10
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CAS#:5447-02-9 3,4-dibenzyloxy... CAS#:3934-87-0 3,4-Dihydroxy-5...

HS Code	2912499000
Summary	2912499000. other aldehyde-ethers, aldehyde-phenols and aldehydes with other oxygen function. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

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Benzaldehyde, 3,4-dihydroxy-

1,2-dihydroxy-4-formylbenzene

3,4-Dihydroxy benzaldehyde

4-formyl-1,2-benzenediol

3,4-Dihydroxybenzyl aldehyde

RANCINAMYCIN IV

MFCD00003370

UNII-4PVP2HCH4T

4-formyl-1,2-dihydroxybenzene

EINECS 205-377-7

3,4-Dihydroxybenzaldehyde

Protocatechuic aldehyde

Protocatechualdehyde

BioBioPha
China
Product Name: 3,4-Dihydroxybenzaldehyde
Price: ￥Inquiry/50mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 3,4-Dihydroxybenzaldehyde
Price: ￥98.0/20mg ￥458.0/100g ￥148.0/25g ￥3588.0/1kg
Purity: 98.0%
Stocking Period: 2 Day
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DC Chemicals Limited
China
Product Name: Protocatechualdehyde
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 3,4-Dihydroxybenzaldehyde
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
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Zhejiang Hangyu API Co., Ltd
China
Product Name: Protocatechualdehyde
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: 3,4-dihydroxybenzaldehyde
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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3,4-Dihydroxybenzaldehyde

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