2-(Chloromethyl)-4-(4-Nitrophenyl)-1,3-Thiazole

Modify Date: 2024-01-02 18:14:25

2-(Chloromethyl)-4-(4-Nitrophenyl)-1,3-Thiazole Structure
2-(Chloromethyl)-4-(4-Nitrophenyl)-1,3-Thiazole structure
Common Name 2-(Chloromethyl)-4-(4-Nitrophenyl)-1,3-Thiazole
CAS Number 89250-26-0 Molecular Weight 254.69
Density 1.4±0.1 g/cm3 Boiling Point 406.2±30.0 °C at 760 mmHg
Molecular Formula C10H7ClN2O2S Melting Point 154.5ºC
MSDS N/A Flash Point 199.5±24.6 °C

 Use of 2-(Chloromethyl)-4-(4-Nitrophenyl)-1,3-Thiazole


2-(Chloromethyl)-4-(4-nitrophenyl)thiazole (Compound APS) has anti-cancer activity in hepatocellular carcinoma (HCC) by repression of M2 polarization of Tumor-associated macrophages (TAMs). 2-(Chloromethyl)-4-(4-nitrophenyl)thiazole can be isolated from Astragalus propinquus Schischk[1].

 Names

Name 2-(Chloromethyl)-4-(4-nitrophenyl)thiazole
Synonym More Synonyms

  Biological Activity

Description 2-(Chloromethyl)-4-(4-nitrophenyl)thiazole (Compound APS) has anti-cancer activity in hepatocellular carcinoma (HCC) by repression of M2 polarization of Tumor-associated macrophages (TAMs). 2-(Chloromethyl)-4-(4-nitrophenyl)thiazole can be isolated from Astragalus propinquus Schischk[1].
Related Catalog
References

[1]. Li C, et al. Astragalus polysacharin inhibits hepatocellular carcinoma-like phenotypes in a murine HCC model through repression of M2 polarization of tumour-associated macrophages. Pharm Biol. 2021 Dec;59(1):1533-1539.  

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 406.2±30.0 °C at 760 mmHg
Melting Point 154.5ºC
Molecular Formula C10H7ClN2O2S
Molecular Weight 254.69
Flash Point 199.5±24.6 °C
Exact Mass 253.991669
PSA 86.95000
LogP 2.71
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.638

 Safety Information

Hazard Codes Xi
Risk Phrases 34
Safety Phrases 22-26-36/37/39-45
HS Code 2932999099

 Synthetic Route

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2-(Chloromethyl)-4-(4-Nitrophenyl)-1,3-Thiazole Structure

2-(Chloromethyl...

CAS#:89250-26-0

Literature: Zhurnal Obshchei Khimii, , vol. 24, p. 1059,1062; engl. Ausg. S. 1057, 1060

~%

2-(Chloromethyl)-4-(4-Nitrophenyl)-1,3-Thiazole Structure

2-(Chloromethyl...

CAS#:89250-26-0

Literature: Zhurnal Obshchei Khimii, , vol. 24, p. 1059,1062; engl. Ausg. S. 1057, 1060

~%

2-(Chloromethyl)-4-(4-Nitrophenyl)-1,3-Thiazole Structure

2-(Chloromethyl...

CAS#:89250-26-0

Literature: Zhurnal Obshchei Khimii, , vol. 24, p. 1059,1062; engl. Ausg. S. 1057, 1060

~%

2-(Chloromethyl)-4-(4-Nitrophenyl)-1,3-Thiazole Structure

2-(Chloromethyl...

CAS#:89250-26-0

Literature: Zhurnal Obshchei Khimii, , vol. 24, p. 1059,1062; engl. Ausg. S. 1057, 1060

 Customs

HS Code 2934100090
Summary 2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

 Synonyms

2-(chloromethyl)-4-(4-nitrophenyl)-1,3-thiazole