1264737-26-9
1264737-26-9 structure
- Name: Gatipotuzumab
- Chemical Name: Gatipotuzumab
- CAS Number: 1264737-26-9
- Molecular Formula:
- Molecular Weight:
- Catalog: Research Areas Cancer
- Create Date: 2023-01-25 08:15:28
- Modify Date: 2024-04-07 15:35:31
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Gatipotuzumab (PankoMab) is a humanized monoclonal antibody which recognizes the tumor-specific epitope of mucin-1 (TA-MUC1). Gatipotuzumab reveals a potent tumor-specific antibody-dependent cell cytotoxicity (ADCC)[1][2].
| Name | Gatipotuzumab |
|---|
| Description | Gatipotuzumab (PankoMab) is a humanized monoclonal antibody which recognizes the tumor-specific epitope of mucin-1 (TA-MUC1). Gatipotuzumab reveals a potent tumor-specific antibody-dependent cell cytotoxicity (ADCC)[1][2]. |
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| Related Catalog | |
| Target |
MUC1[1] |
| In Vitro | Gatipotuzumab (PankoMab) 在 PDTRP 序列的 T 位点被 GalNAcα 糖基化时，强烈结合由 30 个氨基酸组成的 1.5 TRs 的短 MUC1 肽，但如果相同的肽没有糖基化时则不会结合[2]。 Gatipotuzumab (PankoMab) (1 h) 对肿瘤细胞具有高亲和力 (对 NM-D4、ZR75-1、MCF-7 和 T-47D 的 KD 分别为 0.91、3.03、3.84 和 7.14 nM)[2]。 Gatipotuzumab (PankoMab) (0-5 μg/mL; 4 h) 显示特异性的抗肿瘤抗体依赖细胞细胞毒活性[2]。 |
| References |
| No Any Chemical & Physical Properties |