2937327-93-8
2937327-93-8 structure
- Name: BI-2865
- Chemical Name: BI-2865
- CAS Number: 2937327-93-8
- Molecular Formula: C23H27N7O2S
- Molecular Weight: 465.57
- Catalog: Signaling Pathways GPCR/G Protein Ras
- Create Date: 2023-11-25 14:31:41
- Modify Date: 2024-01-03 18:40:09
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BI-2865 is a none-covalent pan-KRAS Inhibitor. BI-2865 binds to WT, G12C, G12D, G12V and G13D mutant KRAS with KDs of 6.9, 4.5, 32, 26, 4.3 nM respectively. BI-2865 inhibits the proliferation of G12C, G12D or G12V mutant KRAS expressing BaF3 cells (mean IC50: roughly 140 nM)[1].
| Name | BI-2865 |
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| Description | BI-2865 is a none-covalent pan-KRAS Inhibitor. BI-2865 binds to WT, G12C, G12D, G12V and G13D mutant KRAS with KDs of 6.9, 4.5, 32, 26, 4.3 nM respectively. BI-2865 inhibits the proliferation of G12C, G12D or G12V mutant KRAS expressing BaF3 cells (mean IC50: roughly 140 nM)[1]. |
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| Density | 1.38±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) |
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| Boiling Point | 708.7±70.0 °C(Predicted) |
| Molecular Formula | C23H27N7O2S |
| Molecular Weight | 465.57 |