Kushenol A

Modify Date: 2024-01-09 13:35:52

Kushenol A Structure
Kushenol A structure
Common Name Kushenol A
CAS Number 99217-63-7 Molecular Weight 408.487
Density 1.2±0.1 g/cm3 Boiling Point 581.7±50.0 °C at 760 mmHg
Molecular Formula C25H28O5 Melting Point N/A
MSDS N/A Flash Point 195.8±23.6 °C

 Use of Kushenol A


Kushenol A is isolated from the root of Sophora flavescent, a non-competitive tyrosinase inhibitor with IC50 and Ki values of 1.1 μM and 0.4 μM, respectively[1].Kushenol A is a flavonoid antioxidant, has inhibitory effects on alpha-glucosidase and beta-amylase[2].Kushenol A is confirmed as potential inhibitors of enzymes targeted by cosmetics for skin whitening and aging[1].

 Names

Name Kushenol A
Synonym More Synonyms

 Kushenol A Biological Activity

Description Kushenol A is isolated from the root of Sophora flavescent, a non-competitive tyrosinase inhibitor with IC50 and Ki values of 1.1 μM and 0.4 μM, respectively[1].Kushenol A is a flavonoid antioxidant, has inhibitory effects on alpha-glucosidase and beta-amylase[2].Kushenol A is confirmed as potential inhibitors of enzymes targeted by cosmetics for skin whitening and aging[1].
Related Catalog
References

[1]. Kim JH, et al. Kushenol A and 8-prenylkaempferol, tyrosinase inhibitors, derived from Sophora flavescens. J Enzyme Inhib Med Chem. 2018 Dec;33(1):1048-1054.

[2]. Kim JH, et al. Glycosidase inhibitory flavonoids from Sophora flavescens. Biol Pharm Bull. 2006 Feb;29(2):302-5.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 581.7±50.0 °C at 760 mmHg
Molecular Formula C25H28O5
Molecular Weight 408.487
Flash Point 195.8±23.6 °C
Exact Mass 408.193665
PSA 86.99000
LogP 7.24
Vapour Pressure 0.0±1.7 mmHg at 25°C
Index of Refraction 1.607
Storage condition 2-8℃

 Safety Information

Hazard Codes Xi

 Synonyms

(2S)-5,7-Dihydroxy-2-(2-hydroxyphenyl)-8-[(2R)-2-isopropenyl-5-methyl-4-hexen-1-yl]-2,3-dihydro-4H-chromen-4-one
4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(2-hydroxyphenyl)-8-[(2R)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-, (2S)-