Aviptadil (INN) is an analog of vasoactive intestinal polypeptide (VIP) for the treatment of erectile dysfunction. Sequence: His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2.
(19R)-13-Deoxy-19-hydroxyenmein is the parent compound of enmein-type diterpenoid analogs. (19R)-13-Deoxy-19-hydroxyenmein has anti-proliferative activities with IC50 values of 0.41, 0.85, 0.43, 1.89 μM against human cancer cell lines K562, MGC-803, CaEs-17, and Bel-7402, respectively[1].
Elephanoside D (compound 8) is a steroidal saponin isolated from the stems of Yucca elephantipes Regel.
NQO1 substrate acts as an efficient NQO1 substrate and may be a new option for the treatment of NQO1-overexpresssing drug-resistant NSCLC[1].
A-196 is a potent and selective chemical inhibitor of SUV420H1 and SUV420H2 that inhibits the di- and trimethylation of H4K20me in multiple cell lines. Target: A-196 is a selective chemical probe for SUV420H1/H2. A-196 is the first potent and selective chemical probe for SUV420H1 and SUV420H2. The in vitro activity of A-196 includes inhibition of SUV420H1 with IC50 = 25 nM and SUV420H2 with IC50 = 144 nM for methylation of H4K20me and greater than 100-fold selectivity over other histone methyltransferases and non-epigenetic targets. In cell assays, A-196 inhibits the di- and tri-methylation of H4K20me in multiple cell lines with IC50 < 1 μM. SUV420H1 and SUV420H2 are two highly homologous methyltransferases that di- and tri-methylate 'Lys-20' of histone H4.
α-Isolupanine is an alkaloid. α-Isolupanine can be isolated from Narrow-Leafed Lupin (PLupinus angustifolius L.). α-Isolupanine can be used for the research of anthracnose[1].
N,N'-Di-BOC-L-cystine is a cysteine derivative[1].
H-Chpro-OH.HCl is a proline derivative[1].
Chaetochromin A (Compound 1) is a fungal metabolite. Chaetochromin A shows inhibitory effect on botulinum neurotoxin serotype A (BoNT A) (IC50= 24.6 μM)[1].
Aflavarin is produced from cluster 39 expressed mainly in sclerotia. Aflavarin exhibits anti-insectan activity [1].
AU-16235 is an inactive epimer of AU-15330. AU-16235 has no effect on cancer cell survival and growth[1]
SHU 9119 is a potent human melanocortin 3 and 4 receptors (MC3/4R) antagonist and a partial MC5R agonist; with IC50 values of 0.23, 0.06, and 0.09 nM for human MC3R, MC4R and MC5R, respectively.
Boc-D-tert-leucine is a leucine derivative[1].
Isopropyl ((R)-(perfluorophenoxy)(phenoxy)phosphoryl)-L-alaninate can be used to synthesis Sofosbuvir (HY-15005) to avoid the production of sofibuvir degradation impurities[1].
L-Biotin, also known as biotin, is a water-soluble vitamin that is an essential cofactor in the carboxylation of several enzymes. L-Biotin is involved in fatty acid synthesis and amino acid metabolism[1].
(S)-6-Amino-2-(2-(2-phenylacetamido)acetamido)hexanoic acid is a lysine derivative[1].
((3-Chloro-4-fluorophenyl)sulfonyl)glycine is a glycine derivative.
QM295 is an endoplasmic reticulum oxidation 1 (ERO1) inhibitor with selectively reversible thiol reactivity. QM295 can be used for the research of endoplasmic reticulum stress[1].
Polythiazide is a potent and orally active thiazide diuretic agent that has antihypertensive effect. Polythiazide can decrease edema and decrease blood pressure. Polythiazide also has phototoxicity[1][2][3].
2-Phenylethyl β-D-galactopyranoside (Phenethyl β-D-galactoside) can be synthesized catalyzed by Aspergillus oryzae β-galactosidase[1].
Kojic acid is a natural substance produced by Aspergillus oryzae, also used as an anti-oxidant and radio-protective agent[1].
FMRF is a peptide consisting of 4 amino acid residues.
Propacetamol hydrochloride is an analgesic agent. Propacetamol hydrochloride also is a precursor form of paracetamol. Propacetamol hydrochloride can be used in postoperative pain, acute trauma and gastrointestinal disorders[1].
Tesnatilimab is a human IgG4 monoclonal antibody that acts on the immune activating receptor NKG2D and has potential immunomodulatory and anti-inflammatory activity. Tesnatilimab can be used in the study of inflammatory bowel disease (IBD)[1].
Fmoc-Ser(tBu)-OH is a serine derivative[1].
(((9H-Fluoren-9-yl)methoxy)carbonyl)-D-methionine is a Methionine (HY-13694) derivative[1].
ACTH (11-24) is a fragment of adrenocorticotrophin, acts as an antagonist of adrenocorticotropic hormone (ACTH) receptor, and induces cortisol release.
3,4,5-Trichlorocatechol is a is a catechol derivative of pentachlorophenol and induces oxidative DNA lesions[1].
Terretonin A is a meroterpenoid that can be isolated from the endophytic fungus Aspergillus terreus[1].