A 196
Modify Date: 2025-11-28 12:13:39
A 196 structure
|
Common Name | A 196 | ||
|---|---|---|---|---|
| CAS Number | 1982372-88-2 | Molecular Weight | 359.25 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H16Cl2N4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of A 196A-196 is a potent and selective chemical inhibitor of SUV420H1 and SUV420H2 that inhibits the di- and trimethylation of H4K20me in multiple cell lines. Target: A-196 is a selective chemical probe for SUV420H1/H2. A-196 is the first potent and selective chemical probe for SUV420H1 and SUV420H2. The in vitro activity of A-196 includes inhibition of SUV420H1 with IC50 = 25 nM and SUV420H2 with IC50 = 144 nM for methylation of H4K20me and greater than 100-fold selectivity over other histone methyltransferases and non-epigenetic targets. In cell assays, A-196 inhibits the di- and tri-methylation of H4K20me in multiple cell lines with IC50 < 1 μM. SUV420H1 and SUV420H2 are two highly homologous methyltransferases that di- and tri-methylate 'Lys-20' of histone H4. |
| Name | A-196 |
|---|---|
| Synonym | More Synonyms |
| Description | A-196 is a potent and selective chemical inhibitor of SUV420H1 and SUV420H2 that inhibits the di- and trimethylation of H4K20me in multiple cell lines. Target: A-196 is a selective chemical probe for SUV420H1/H2. A-196 is the first potent and selective chemical probe for SUV420H1 and SUV420H2. The in vitro activity of A-196 includes inhibition of SUV420H1 with IC50 = 25 nM and SUV420H2 with IC50 = 144 nM for methylation of H4K20me and greater than 100-fold selectivity over other histone methyltransferases and non-epigenetic targets. In cell assays, A-196 inhibits the di- and tri-methylation of H4K20me in multiple cell lines with IC50 < 1 μM. SUV420H1 and SUV420H2 are two highly homologous methyltransferases that di- and tri-methylate 'Lys-20' of histone H4. |
|---|---|
| Related Catalog |
| Molecular Formula | C18H16Cl2N4 |
|---|---|
| Molecular Weight | 359.25 |
| InChIKey | ABGOSOMRWSYAOB-UHFFFAOYSA-N |
| SMILES | Clc1cc2c(NC3CCCC3)nnc(-c3ccncc3)c2cc1Cl |
| Storage condition | -20℃ |
| MFCD29924807 |