polythiazide (200 mg)

Modify Date: 2025-08-25 10:22:56

polythiazide (200 mg) Structure
polythiazide (200 mg) structure
 Common Name polythiazide (200 mg)
CAS Number 346-18-9 Molecular Weight 439.88200
Density 1.598g/cm3 Boiling Point 580.1ºC at 760mmHg
Molecular Formula C11H13ClF3N3O4S3 Melting Point 202.5°
MSDS N/A Flash Point 304.7ºC

 Use of polythiazide (200 mg)


Polythiazide is a potent and orally active thiazide diuretic agent that has antihypertensive effect. Polythiazide can decrease edema and decrease blood pressure. Polythiazide also has phototoxicity[1][2][3].

 Names

Name 6-chloro-2-methyl-1,1-dioxo-3-(2,2,2-trifluoroethylsulfanylmethyl)-3,4-dihydro-1λ6,2,4-benzothiadiazine-7-sulfonamide
Synonym More Synonyms

 polythiazide (200 mg) Biological Activity

Description Polythiazide is a potent and orally active thiazide diuretic agent that has antihypertensive effect. Polythiazide can decrease edema and decrease blood pressure. Polythiazide also has phototoxicity[1][2][3].
Related Catalog
In Vitro Polythiazide (500 μM, 1 min) induces significant phototoxic NHIK 3025 cell death under Bluelight 2000 apparatus (Ex: 325 nM)[2].
In Vivo Polythiazide (oral gavage, 10 mg/kg, daily for 5 days) Increased plasma cholesterol levels in Cholesterol-fed C57BL/cdJ mouse[3]. Polythiazide (Oral administration, 0.4 mg/k g) shows diuretic and saluretic effects in hypertensive dogs and rats[1]. Animal Model: Cholesterol-fed C57BL/cdJ mice[3] Dosage: 10 mg/kg Administration: Oral gavage, daily for 5 days Result: Caused approximately 13% rise in total plasma cholesterol levels, and increased non-HDL lipoprotein fraction. Animal Model: Hypertensive dogs[1] Dosage: 0.4 mg/kg Administration: Oral administration, daily for 5 days Result: Increased in excretion of sodium and chloride. Animal Model: Hypertensive rats[1] Dosage: 0.05, 0.1, 0.2, 0.4 mg/k g Administration: Oral administration, twice a day for 3 days. Result: Displayed natriuretic and chloruretic effects.
References

[1]. A SCRIABINE, et al. Pharmacological studies with polythiazide, a new diuretic and antihypertensive agent. Proc Soc Exp Biol Med. 1961 Aug-Sep;107:864-72.

[2]. E Selvaag, et al. Phototoxicity due to sulphonamide derived oral antidiabetics and diuretics: investigations in a cell culture model. Photodermatol Photoimmunol Photomed. 1996 Feb;12(1):1-6.

[3]. M N Krupp, et al. Effects of doxazosin and other antihypertensives on serum lipid levels and lipoprotein lipase in the C57BR/cdJ mouse. J Cardiovasc Pharmacol. 1989;13 Suppl 2:S11-8; discussion S18-9.

 Chemical & Physical Properties

Density 1.598g/cm3
Boiling Point 580.1ºC at 760mmHg
Melting Point 202.5°
Molecular Formula C11H13ClF3N3O4S3
Molecular Weight 439.88200
Flash Point 304.7ºC
Exact Mass 438.97100
PSA 151.63000
LogP 4.59280
Index of Refraction 1.566
InChIKey CYLWJCABXYDINA-UHFFFAOYSA-N
SMILES CN1C(CSCC(F)(F)F)Nc2cc(Cl)c(S(N)(=O)=O)cc2S1(=O)=O

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DK9275000
CHEMICAL NAME :
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-2-methyl- 3-(((2,2,2-trifluoroethyl)thio)methyl)-, 1,1-dioxide
CAS REGISTRY NUMBER :
346-18-9
LAST UPDATED :
199709
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C11-H13-Cl-F3-N3-O4-S3
MOLECULAR WEIGHT :
439.90
WISWESSER LINE NOTATION :
T66 BSWN EM DHJ C1 D1S1XFFF HG ISZW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
300 ug/kg/5D-I
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - coma Nutritional and Gross Metabolic - other changes
REFERENCE :
AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946- Volume(issue)/page/year: 70,1163,1981
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>10 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 21,775,1979
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,97,1969
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,793,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 21,775,1979
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
450 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,97,1969

 Synonyms

Polythiazide
Polythiazidum
Politiazida
Nephril
P-2525
Renese
Drenusil
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.
Top Suppliers:I want be here

Get all suppliers and price by the below link:

polythiazide (200 mg) suppliers

polythiazide (200 mg) price

Related Compounds: More...
CEPHRADINE (200 MG)
58456-86-3
haloprogin (200 mg)
777-11-7
Sucromalt (200 mg)
911432-63-8
GADOVERSETAMIDE (200 MG)
131069-91-5
ipodate sodium (200 mg)
1221-56-3
iocetamic acid (200 mg)
16034-77-8
IPODATE CALCIUM (200 MG)
1151-11-7
Aminopentamide Sulfate (200 mg)
5897-62-1
Candicidin
1403-17-4
(4aS,4bS,5R,6aS,7S,9aS,9bS,11aS)-Tetradecahydro-5,7-dihydroxy-4a,6a,7-trimethylcyclopenta[5,6]naphtho[1,2-c]pyran-2(1H)-one
1207298-35-8
(4aR,4bS,6aS,7S,9aS,9bR,11S,11aS)-Tetradecahydro-7,11-dihydroxy-4a,6a,7-trimethylcyclopenta[5,6]naphtho[1,2-c]pyran-2(1H)-one
1207298-36-9
(4aR,4bR,6aS,7S,9aS,9bS,11aS)-Tetradecahydro-4b,7-dihydroxy-4a,6a,7-trimethylcyclopenta[5,6]naphtho[1,2-c]pyran-2(1H)-one
1207298-37-0
(5-tert-butyl-2-m-tolyl-2H-pyrazol-3-yl)-carbamic acid 2,2,2-trichloro-ethyl ester
1160934-76-8
2-[(6-Chloro-2-hydroxy-4-phenylquinolin-3-yl)sulfanyl]-4,6-dimethylpyridine-3-carbonitrile
1203272-33-6
Methyl 5-ethynyl-2-methoxybenzoate
1202818-90-3
I+/--[[[[3-Methoxy-2-[(3-methylphenyl)methoxy]phenyl]methyl]amino]methyl]benzenemethanol
1217013-39-2
3-Isonicotinoyl-9-{2-[(2-methylprop-2-en-1-yl)oxy]benzyl}-3,9-diazaspiro[5.5]undecane
851325-32-1
tert-Butyl 4-oxo-3,4-dihydrospiro[1-benzopyran-2,3'-piperidine]-1'-carboxylate
1013334-97-8
3-(1-Isopropyl-5-oxopyrrolidine-3-carboxamido)propanoic acid
1099107-89-7
Chemsrc provides polythiazide (200 mg)(CAS#:346-18-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of polythiazide (200 mg) are included as well.>> amp version: polythiazide (200 mg)

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved