5-O-Demethyl-28-hydroxy-Avermectin A1a is a degradation product of Avermectin B1a (HY-15308).
Sarcosine ethyl ester hydrochloride is a Glycine (HY-Y0966) derivative[1].
Ethyl pyruvate is a simple derivative of the endogenous metabolite, pyruvic acid. Ethyl pyruvate is an anti-inflammatory agent[1].
4-Fluorobenzoic-2,3,5,6-d4 acid is the deuterium labeled 4-Fluorobenzoic-2,3,5,6-d4 acid[1].
5-Hydroxyomeprazole is the major metabolite of Omeprazole (HY-B0113).
Eliglustat is an specific, potent and orally active glucocerebroside synthase inhibitor with an IC50 of 24 nM.
SOD1-Derlin-1 inhibitor 56-59 is a cell-permeable, small molecule inhibitor of SOD1-Derlin-1 interaction, target SOD1 DBR and clearly attenuates the interactions of Derlin-1 with 122 types of SOD1mut in the cell-based co-immunoprecipitation assay; significantly ameliorates the ALS pathology both in motoneurons derived from patient induced pluripotent stem cells and in model mice.
Kuromanin (chloride), extracted from mulberry leaves, has been shown to improve blood glucose concentrations and lipid homeostasis and to reduce obesity.
Z-D-Phg-OH (D-Cbz phenylglycine) is a N-blocked amino acids with Kd values of 390 μM and 323 μM for tBuCQN and tBuCQD, respectively[1].
Methylsyringin exhibits anti-inflammatory activity in the LPS-stimulated RAW264.7 cells.
3-Pyridinecarboxaldehyde-d4 is the deuterium labeled 3-Pyridinecarboxaldehyde[1].
NHS-MMAF is a modified MMAF extracted from patent WO2012143499, intermediat 219. MMAF is a potent tubulin polymerization inhibitor and is used as a antitumor agent[1]
Z-dehydro-Ala-OH is an alanine derivative[1].
Norelgestromin is a metabolite of Norgestimate, which is a progestin or synthetic progestogen.
Resibufagin is a kind of bufadienolide isolated from the venom of Bufo bufo gargarizans, has anti-tumor activities[1].
β-Interleukin I (163-171), human, an immunostimulatory fragment of human IL-1β peptide, is a T cell activator. β-Interleukin I (163-171), human is not an IL-1R-binding domain of IL-1β. β-Interleukin I (163-171), human is a potent adjuvant that enhances the immune response in a variety of exptl. situations[1][3][4].
Polyoxyl 8 stearate can be used as an excipient. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1].
3,5-Dinitrocatechol (OR-486) is a potent catechol-O-methyltransferase inhibitor, with an IC50 of 12 nM. 3,5-Dinitrocatechol can be used in the preparation of the molybdenum (VI)- 3,5-Dinitrocatechol complex[1][2][3].
pTH-Related Protein (1-34) amide (human, mouse, rat) (Human PTHrP-(1-34)NH2) is a N-terminal fragments of PTHrP. pTH-Related Protein (1-34) amide (human, mouse, rat) induces hypercalcemia, and can be used for research of humoral hypercalcaemia of malignancy[1].
Carbutamide (BZ-55) is an orally active and first-generation sulfonylurea with hypoglycemic activity[1].
TM-25659 is a TAZ modulator. Anti-osteoporotic and anti-obesity activities[1].
Plm IV inhibitor-1 (compound 6) is a potent plasmepsin IV (Plm IV) inhibitor with IC50s of 4.1, 0.80, 0.25, 0.35 µM for Plm I, Plm II, Plm IV, Cat D, respectively[1].
Fmoc-Phe(2-F)-OH is a phenylalanine derivative[1].
THPN is a potent Nur77 agonist. THPN specifically binds the LBD of Nur77 (TR3) but not that of retinoic acid receptor α and PPARγ with a Kd of 270 nM. THPN leads to Nur77 translocation to the mitochondria to induce autophagic cell death in melanoma[1][2].
Cloxyfonac is a plant growth regulator and a chemical transformation product; Pesticide agent.
Deferasirox Fe3+ chelate is a rationally-designed oral iron chelator; its main use is to reduce chronic iron overload in patients who are receiving long-term blood transfusions for conditions such as beta-thalassemia and other chronic anemias.
Azoxymethane is a colon carcinogen which leads to the formation of DNA adducts.
ChemR23-IN-2 is a potent and orally efficacious ChemR23 inhibitor with an IC50 value of 3.2 nM.
Triacylglycerol lipase is an enzyme that preferentially hydrolyzes the outer links of triacylglycerols and acts only on the water-lipid interface. Pancreatic triacylglycerol lipase is the single most important determinant of lipid absorption[1].
N-(2-Hydroxyphenyl)picolinamide is an active molecule.