100079-26-3

100079-26-3 structure

Name: THPN
Chemical Name: 1-(3,4,5-trihydroxyphenyl)nonan-1-one
CAS Number: 100079-26-3
Molecular Formula: C₁₅H₂₂O₄
Molecular Weight: 266.33300
Catalog: Research Areas Inflammation/Immunology
Create Date: 2017-10-18 09:57:27
Modify Date: 2024-01-27 09:13:39
THPN is a potent Nur77 agonist. THPN specifically binds the LBD of Nur77 (TR3) but not that of retinoic acid receptor α and PPARγ with a Kd of 270 nM. THPN leads to Nur77 translocation to the mitochondria to induce autophagic cell death in melanoma[1][2].

Name	1-(3,4,5-trihydroxyphenyl)nonan-1-one
Synonyms	1-(3,4,5)-Trihydroxyphenyl)nonan-1-one 1-(2,4,6-Trihydroxyphenyl)-1-nonanone 1-Nonanone,1-(2,4,6-trihydroxyphenyl) 1,2,3-Benzenetriol,4-(octylcarbonyl) T94

Description	THPN is a potent Nur77 agonist. THPN specifically binds the LBD of Nur77 (TR3) but not that of retinoic acid receptor α and PPARγ with a Kd of 270 nM. THPN leads to Nur77 translocation to the mitochondria to induce autophagic cell death in melanoma[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
References	[1]. Wei-jia Wang, et al. Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway. Nat Chem Biol. 2014 Feb;10(2):133-40. [2]. Li Li, et al. Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation. Nat Chem Biol. 2015 May;11(5):339-46.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Precautionary Statements	P301 + P312 + P330
Hazard Codes	Xn
RIDADR	NONH for all modes of transport