260553-97-7
260553-97-7 structure
- Name: TM-25659
- Chemical Name: TM-25659
- CAS Number: 260553-97-7
- Molecular Formula: C30H28N8
- Molecular Weight: 500.60
- Catalog: Research Areas Metabolic Disease
- Create Date: 2019-03-03 12:15:03
- Modify Date: 2024-01-08 19:54:15
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TM-25659 is a TAZ modulator. Anti-osteoporotic and anti-obesity activities[1].
| Name | TM-25659 |
|---|
| Description | TM-25659 is a TAZ modulator. Anti-osteoporotic and anti-obesity activities[1]. |
|---|---|
| Related Catalog | |
| Target |
TAZ[1] |
| In Vitro | TM-25659 (2, 10, 20, 100 μM) enhances nuclear TAZ localization in a dose-dependent manner and attenuates PPARγ-mediated adipocyte differentiation by facilitating PPARγ suppression activity of TAZ[1]. |
| In Vivo | Oral administration of TM-25659 has a favourable pharmacokinetic profile. TM-25659 (50 mg/kg) suppresses bone loss in vivo and decreases weight gain in an obesity model[1]. |
| References |
| Molecular Formula | C30H28N8 |
|---|---|
| Molecular Weight | 500.60 |
| Storage condition | 2-8℃ |