TM-25659

Modify Date: 2024-01-08 19:54:15

TM-25659 structure	Common Name	TM-25659
	CAS Number	260553-97-7	Molecular Weight	500.60
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₀H₂₈N₈	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of TM-25659

TM-25659 is a TAZ modulator. Anti-osteoporotic and anti-obesity activities[1].

Name	TM-25659

Description	TM-25659 is a TAZ modulator. Anti-osteoporotic and anti-obesity activities[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
Target	TAZ[1]
In Vitro	TM-25659 (2, 10, 20, 100 μM) enhances nuclear TAZ localization in a dose-dependent manner and attenuates PPARγ-mediated adipocyte differentiation by facilitating PPARγ suppression activity of TAZ[1].
In Vivo	Oral administration of TM-25659 has a favourable pharmacokinetic profile. TM-25659 (50 mg/kg) suppresses bone loss in vivo and decreases weight gain in an obesity model[1].
References	[1]. Jang EJ, et al. TM-25659 enhances osteogenic differentiation and suppresses adipogenic differentiation by modulating the transcriptional co-activator TAZ. Br J Pharmacol. 2012 Mar;165(5):1584-94.

Molecular Formula	C₃₀H₂₈N₈
Molecular Weight	500.60
Storage condition	2-8℃

DC Chemicals Limited
China
Product Name: TM-25659
Price: $1300.0/100mg $2600.0/250mg $5200.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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Price: ￥3855/10 mM * 1 mL in DMSO

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