PROTAC Linker

Total: 1884
Updated: 2019-06-28 15:55:20
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.

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PI3K/Akt/mTOR >
Akt AMPK ATM/ATR DNA-PK GSK-3 MELK mTOR PDK-1 PI3K PI4K PIKfyve PTEN
PROTAC >
PROTAC E3 Ligase Ligand-Linker Conjugate Ligand for E3 Ligase PROTAC Linker PROTAC-linker Conjugate for PAC
Protein Tyrosine Kinase/RTK >
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DBCO-PEG2-amine

DBCO-PEG2-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2250216-96-5
  • MF: C25H29N3O4
  • MW: 435.52
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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DBCO-PEG2-acid

DBCO-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2304558-25-4
  • MF: C26H28N2O6
  • MW: 464.51
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Propargyl-PEG3-methane

Propargyl-PEG3-methane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 89635-82-5
  • MF: C10H18O4
  • MW: 202.24800
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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m-PEG2-O-Ph-3-NH2

m-PEG2-O-Ph-3-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 126415-02-9
  • MF: C11H17NO3
  • MW: 211.258
  • Catalog: PROTAC Linker
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 346.2±27.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 173.9±17.4 °C
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Hydroxy-PEG4-CH2-Boc

Hydroxy-PEG4-CH2-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

  • CAS Number: 169751-72-8
  • MF: C14H28O7
  • MW: 308.368
  • Catalog: PROTAC Linker
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 393.1±32.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 132.9±18.6 °C
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BnO-PEG4-Boc

BnO-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1807503-89-4
  • MF: C21H34O7
  • MW: 398.491
  • Catalog: PROTAC Linker
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 472.2±40.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 201.2±27.4 °C
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Azido-PEG1-methyl ester

Azido-PEG1-methyl ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1835759-80-2
  • MF: C6H11N3O3
  • MW: 173.17
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Azido-PEG1-CH2COO-Cl

Azido-PEG1-CH2COO-Cl (compound 43a) is an alkyl/ether-based PROTAC linker. Azido-PEG1-CH2COO-Cl can be used in the synthesis of PROTAC BRD4 Degrader-1 (HY-133131)[1].

  • CAS Number: 79598-49-5
  • MF: C4H6ClN3O2
  • MW: 163.56
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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m-PEG2-azide

m-PEG2-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

  • CAS Number: 215181-61-6
  • MF: C5H11N3O2
  • MW: 145.160
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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HS-PEG5-CH2CH2N3

HS-PEG5-CH2CH2N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1449390-11-7
  • MF: C12H25N3O5S
  • MW: 323.41
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Azido-PEG1-CH2CO2H

Azido-PEG1-CH2CO2H is a PROTAC linker, which refers to the alkyl/ether composition. Azido-PEG1-CH2CO2H can be used in the synthesis of PROTAC BRD4 Degrader-1[1].

  • CAS Number: 79598-48-4
  • MF: C4H7N3O3
  • MW: 145.117
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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BnO-PEG5-OH

BnO-PEG5-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

  • CAS Number: 57671-28-0
  • MF: C17H28O6
  • MW: 328.401
  • Catalog: PROTAC Linker
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 437.2±40.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 218.2±27.3 °C
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mPEG11-Br

m-PEG11-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1258596-39-2
  • MF: C23H47BrO11
  • MW: 579.52
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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1-Cbz-3-Hydroxyazetidine

1-Cbz-3-Hydroxyazetidine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-Cbz-3-Hydroxyazetidine is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

  • CAS Number: 128117-22-6
  • MF: C11H13NO3
  • MW: 207.226
  • Catalog: ADC Linker
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: 356.7±42.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 169.5±27.9 °C
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Hydroxy-Amino-bis(PEG2-propargyl)

Hydroxy-Amino-bis(PEG2-propargyl) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2100306-77-0
  • MF: C16H27NO5
  • MW: 313.39
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Azido-PEG2-CH2COOH

Azido-PEG2-CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

  • CAS Number: 882518-90-3
  • MF: C6H11N3O4
  • MW: 189.16900
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Thalidomide-O-PEG4-azide

Thalidomide-O-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2380318-57-8
  • MF: C23H29N5O9
  • MW: 519.50
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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m-PEG5-acid

m-PEG5-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

  • CAS Number: 81836-43-3
  • MF: C12H24O7
  • MW: 280.31500
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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m-PEG4-(CH2)3-alcohol

m-PEG4-CH2-alcohol is PEG-based based PROTAC linker can be used in the synthesis of PROTACs.

  • CAS Number: 145526-76-7
  • MF: C10H22O5
  • MW: 222.28
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Boc-aminoxy-PEG4-acid

Boc-aminoxy-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2062663-68-5
  • MF: C16H31NO9
  • MW: 381.42
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Propargyl-PEG2-urea-C3-triethoxysilane

Propargyl-PEG2-urea-C3-triethoxysilane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1637329-79-3
  • MF: C17H34N2O6Si
  • MW: 390.55
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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t-Boc-Aminooxy-PEG5-azide

t-Boc-Aminooxy-PEG5-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2250216-95-4
  • MF: C17H34N4O8
  • MW: 422.47
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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TFP-PEG3-TFP

TFP-PEG3-TFP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1446282-34-3
  • MF: C22H18F8O7
  • MW: 546.36
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Azido-C1-PEG3-C3-NH2

Azido-C1-PEG3-C3-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1162336-72-2
  • MF: C10H22N4O3
  • MW: 246.30700
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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m-PEG8-azide

m-PEG8-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

  • CAS Number: 869718-80-9
  • MF: C17H35N3O8
  • MW: 409.47500
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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tert-Butyl ((17-amino-3,6,9,12,15-pentaoxaheptadecyl)oxy)carbamate

Boc-Aminooxy-PEG5-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2250216-94-3
  • MF: C17H36N2O8
  • MW: 396.48
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Methylamino-PEG4-acid HCl

Methylamino-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1283658-71-8
  • MF: C12H25NO6
  • MW: 279.330
  • Catalog: PROTAC Linker
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 405.5±40.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 199.1±27.3 °C
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Azido-PEG3-succinimidyl carbonate

Azido-PEG3-O-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2110448-98-9
  • MF: C13H20N4O8
  • MW: 360.32
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Azido-PEG8-NHBoc

Azido-PEG8-NHBoc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

  • CAS Number: 2231845-12-6
  • MF: C23H46N4O10
  • MW: 538.63
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Aminooxy-PEG2-alcohol

Aminooxy-PEG2-alcohol is a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Aminooxy-PEG2-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].

  • CAS Number: 185022-12-2
  • MF: C4H11NO3
  • MW: 121.14
  • Catalog: ADC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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