PROTAC Linker

Total: 1884
Updated: 2019-06-28 15:55:20
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.

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NF-κB >
NF-κB IKK Keap1-Nrf2 MALT1
PI3K/Akt/mTOR >
Akt AMPK ATM/ATR DNA-PK GSK-3 MELK mTOR PDK-1 PI3K PI4K PIKfyve PTEN
PROTAC >
PROTAC E3 Ligase Ligand-Linker Conjugate Ligand for E3 Ligase PROTAC Linker PROTAC-linker Conjugate for PAC
Protein Tyrosine Kinase/RTK >
Ack1 ALK Bcr-Abl BMX Kinase Btk c-Fms c-Kit c-Met/HGFR Discoidin Domain Receptor DYRK EGFR Ephrin Receptor FAK FGFR FLT3 IGF-1R Insulin Receptor IRAK Itk PDGFR PKA Pyk2 ROS Src Syk TAM Receptor Trk Receptor VEGFR
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TGF-beta/Smad >
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Vitamin D Related >
VD/VDR
Others >
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Azido-PEG4-propargyl

Azido-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1192590-91-2
  • MF: C11H19N3O4
  • MW: 257.29
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Propargyl-PEG8-Boc

Propargyl-PEG7-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

  • CAS Number: 2055014-96-3
  • MF: C24H44O10
  • MW: 492.600
  • Catalog: PROTAC Linker
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 528.4±45.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 220.3±28.8 °C
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Ald-PEG1-t-butyl ester

Ald-PEG1-C2-Boc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2100306-48-5
  • MF: C10H18O4
  • MW: 202.25
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Aminooxy-PEG4-propargyl

Aminooxy-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1835759-78-8
  • MF: C11H21NO5
  • MW: 247.29
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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N-(m-PEG4)-N'-(PEG2-acid)-Cy5

N-(m-PEG4)-N'-(PEG2-acid)-Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2107273-24-3
  • MF: C41H57ClN2O8
  • MW: 741.35
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Azido-PEG7-CH2COOH

Azido-PEG7-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1446411-32-0
  • MF: C16H31N3O9
  • MW: 409.43
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Propargyl-PEG3-phosphonic acid

Propargyl-PEG3-phosphonic acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

  • CAS Number: 1714139-62-4
  • MF: C9H17O6P
  • MW: 252.20
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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S-Acetyl-PEG3-azide

S-Acetyl-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1310827-26-9
  • MF: C10H19N3O4S
  • MW: 277.341
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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N-(Azido-PEG3)-N-Boc-PEG4-NHS ester

N-(Azido-PEG4)-N-Boc-PEG4-NHS ester is a PEG-based PROTAC linker with a terminal azide group. N-(Azido-PEG4)-N-Boc-PEG4-NHS ester is used in the synthesis of PROTACs[1]

  • CAS Number: 2112731-96-9
  • MF: C28H49N5O13
  • MW: 663.71
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Boc-NH-PEG7-acid

Boc-NH-PEG7-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2055044-68-1
  • MF: C22H43NO11
  • MW: 497.577
  • Catalog: PROTAC Linker
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 598.4±50.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 315.7±30.1 °C
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HO-PEG16-OH

HO-PEG16-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 6812-36-8
  • MF: C32H66O17
  • MW: 722.85600
  • Catalog: PROTAC Linker
  • Density: 1.116g/cm3
  • Boiling Point: 714.7ºC at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 386.1ºC
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N-(Amino-PEG1)-N-bis(PEG2-propargyl)

N-(Amino-PEG1)-N-bis(PEG2-propargyl) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2100306-47-4
  • MF: C18H32N2O5
  • MW: 356.457
  • Catalog: PROTAC Linker
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 443.9±40.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 222.2±27.3 °C
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DBCO-PEG9-DBCO

DBCO-PEG9-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2353409-50-2
  • MF: C58H70N4O13
  • MW: 1031.20
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Benzyl-PEG2-ethanol

Benzyl-PEG2-ethanol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2055300-50-8
  • MF: C13H20O3
  • MW: 224.30
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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2-(3,6-Bis(dimethylamino)xanthylium-9-yl)-5-((2-(2-(2-(2-(4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenoxy)ethoxy)ethoxy)ethoxy)ethyl)carbamoyl)benzoate

TAMRA-PEG4-methyltetrazine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2163772-19-6
  • MF: C42H45N7O8
  • MW: 775.85
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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N-(Amino-PEG4)-N-bis(PEG4-t-butyl ester)

N-(Amino-PEG4)-N-bis(PEG4-Boc) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2093153-97-8
  • MF: C40H80N2O16
  • MW: 845.07
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Acid-C2-PEG3-NHS ester

Acid-C2-PEG3-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1835759-79-9
  • MF: C14H21NO9
  • MW: 347.318
  • Catalog: PROTAC Linker
  • Density: 1.4±0.1 g/cm3
  • Boiling Point: 516.1±60.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 265.9±32.9 °C
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Propargyl-PEG9-OH

Propargyl-PEG9-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

  • CAS Number: 2055022-35-8
  • MF: C21H40O10
  • MW: 452.536
  • Catalog: PROTAC Linker
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 518.0±45.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 267.1±28.7 °C
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Propargyl-PEG4-tetra-Ac-beta-D-glucose

Propargyl-PEG4-tetra-Ac-beta-D-glucose is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1360446-31-6
  • MF: C25H38O14
  • MW: 562.559999999999
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Azido-PEG3-SS-PEG3-azide

Azido-PEG3-SS-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1310827-27-0
  • MF: C16H32N6O6S2
  • MW: 468.592
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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S-acetyl-PEG3-alcohol

S-acetyl-PEG3-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 153870-20-3
  • MF: C8H16O4S
  • MW: 208.27500
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Iodo-PEG4-N3

Iodo-PEG4-N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 936917-36-1
  • MF: C8H16IN3O3
  • MW: 329.135
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Azido-PEG24-NHS ester

Azido-PEG24-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2375600-46-5
  • MF: C55H104N4O28
  • MW: 1269.42
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Biotin-PEG6-NHS ester

Biotin-PEG6-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2055045-04-8
  • MF: C29H48N4O12S
  • MW: 676.78
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Tos-PEG8-Tos

Tos-PEG8-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 57436-38-1
  • MF: C30H46O13S2
  • MW: 678.80800
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Fmoc-PEG3-alcohol

Fmoc-PEG3-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 560088-66-6
  • MF: C21H25NO5
  • MW: 371.42700
  • Catalog: PROTAC Linker
  • Density: 1.208g/cm3
  • Boiling Point: 581.5ºC at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 305.5ºC
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DNP-PEG4-t-butyl ester

DNP-NH-PEG4-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1817735-31-1
  • MF: C21H33N3O10
  • MW: 487.50
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Ald-CH2-PEG4-Boc

Ald-CH2-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1415329-20-2
  • MF: C15H28O7
  • MW: 320.379
  • Catalog: PROTAC Linker
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 401.7±35.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 173.2±26.0 °C
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Benzyl-PEG9-alcohol

Benzyl-PEG9-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 868594-48-3
  • MF: C25H44O10
  • MW: 504.61100
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Boc-PEG4-acid

Boc-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2244684-38-4
  • MF: C16H30O9
  • MW: 366.40
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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