57436-38-1
57436-38-1 structure
- Name: Tos-PEG8-Tos
- Chemical Name: 2-[2-[2-[2-[2-[2-[2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate
- CAS Number: 57436-38-1
- Molecular Formula: C30H46O13S2
- Molecular Weight: 678.80800
- Catalog: Signaling Pathways PROTAC PROTAC Linker
- Create Date: 2017-03-02 12:58:27
- Modify Date: 2025-09-01 10:13:55
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Tos-PEG8-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
| Name | 2-[2-[2-[2-[2-[2-[2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate |
|---|---|
| Synonyms |
1,24-bis(tosyloxy)-3,6,9,12,15,18,21-heptaoxatetracosane
Octaethylene glycol di(p-toluenesulfonate) Octaethylene glycol ditosylate 3,6,9,12,15,18,21-Heptaoxatricosane-1,23-diyl bis(4-methylbenzenesulfonate) 1,23-bis(tosyloxy)-3,6,9,12,15,18,21-heptaoxatricosane |
| Description | Tos-PEG8-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
|---|---|
| Related Catalog | |
| Target |
PEGs |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
| Molecular Formula | C30H46O13S2 |
|---|---|
| Molecular Weight | 678.80800 |
| Exact Mass | 678.23800 |
| PSA | 168.11000 |
| LogP | 4.69200 |
|
~99%
57436-38-1 |
| Literature: Chen, Yiyan; Baker, Gregory L. Journal of Organic Chemistry, 1999 , vol. 64, # 18 p. 6870 - 6873 |
|
~%
57436-38-1 |
| Literature: Chen, Yiyan; Baker, Gregory L. Journal of Organic Chemistry, 1999 , vol. 64, # 18 p. 6870 - 6873 |
|
~%
57436-38-1 |
| Literature: Chen, Yiyan; Baker, Gregory L. Journal of Organic Chemistry, 1999 , vol. 64, # 18 p. 6870 - 6873 |
|
~%
57436-38-1 |
| Literature: Chen, Yiyan; Baker, Gregory L. Journal of Organic Chemistry, 1999 , vol. 64, # 18 p. 6870 - 6873 |
| Precursor 4 | |
|---|---|
| DownStream 1 | |
