PROTAC Linker

Total: 1884
Updated: 2019-06-28 15:55:20
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.

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Akt AMPK ATM/ATR DNA-PK GSK-3 MELK mTOR PDK-1 PI3K PI4K PIKfyve PTEN
PROTAC >
PROTAC E3 Ligase Ligand-Linker Conjugate Ligand for E3 Ligase PROTAC Linker PROTAC-linker Conjugate for PAC
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Amino-PEG4-Boc

Amino-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 581065-95-4
  • MF: C15H31NO6
  • MW: 321.41000
  • Catalog: PROTAC Linker
  • Density: 1.040±0.06 g/cm3
  • Boiling Point: 400.1±35.0 ºC (760 Torr)
  • Melting Point: N/A
  • Flash Point: 114.1±22.3 ºC
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Azido-PEG3-Val-Cit-PAB-PNP

Azido-PEG3-Val-Cit-PAB-PNP is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azido-PEG3-Val-Cit-PAB-PNP is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].

  • CAS Number: 2055047-18-0
  • MF: C34H47N9O12
  • MW: 773.79
  • Catalog: ADC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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11-Aminoundecanoic acid

11-Aminoundecanoic acid is a PROTAC linker, which refers to the alkyl chain composition. 11-Aminoundecanoic acid can be used in the synthesis of a series of PROTACs.

  • CAS Number: 2432-99-7
  • MF: C11H23NO2
  • MW: 201.306
  • Catalog: PROTAC Linker
  • Density: 1.0±0.1 g/cm3
  • Boiling Point: 334.9±15.0 °C at 760 mmHg
  • Melting Point: 188-191 °C(lit.)
  • Flash Point: 156.3±20.4 °C
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Bromo-PEG2-MS

Bromo-PEG2-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1935075-34-5
  • MF: C5H11BrO4S
  • MW: 247.11
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Biotin-PEG4-amide-Alkyne

Biotin-PEG4-amide-Alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1006592-45-5
  • MF: C24H40N4O7S
  • MW: 528.662
  • Catalog: PROTAC Linker
  • Density: 1.174
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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N33-TEG-COOH

N33-TEG-COOH is a PROTAC linker containing four polyethylene glycol (PEG) units.

  • CAS Number: 201467-81-4
  • MF: C10H19N3O6
  • MW: 277.27400
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Methylamino-PEG3-t-butyl ester

Methylamino-PEG3-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 217817-03-3
  • MF: C14H29NO5
  • MW: 291.38
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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1,1,1-Trifluoroethyl-PEG3-Propargyl

1,1,1-Trifluoroethyl-PEG2-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1835759-73-3
  • MF: C9H13F3O3
  • MW: 226.19
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Hydroxy-PEG2-CH2COOH

Hydroxy-PEG2-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 51951-04-3
  • MF: C6H12O5
  • MW: 164.156
  • Catalog: PROTAC Linker
  • Density: 1.2±0.0 g/cm3
  • Boiling Point: 343.4±0.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 144.3±0.0 °C
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m-PEG12-NH-C2-acid

m-PEG12-NH-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1949843-39-3
  • MF: C28H57NO14
  • MW: 631.75
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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THP-PEG10-THP

THP-PEG10-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 42749-29-1
  • MF: C30H58O13
  • MW: 626.77
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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N-Boc-piperazine-C3-COOH

N-Boc-piperazine-C3-COOH is a PROTAC linker, which refers to the alkyl/ether composition. Boc-N-piperazine-C3-COOH can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1 (HY-131183)[1].

  • CAS Number: 959053-53-3
  • MF: C14H24N2O5
  • MW: 300.35
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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t-Boc-aminooxy-PEG1-propargyl

Boc-aminooxy-PEG1-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1895922-72-1
  • MF: C10H17NO4
  • MW: 215.25
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Amino-PEG11-acid

Amino-PEG11-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1616426-12-0
  • MF: C25H51NO13
  • MW: 573.67
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Bromo-PEG4-bromide

Bromo-PEG4-bromide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

  • CAS Number: 57602-02-5
  • MF: C10H20Br2O4
  • MW: 364.071
  • Catalog: PROTAC Linker
  • Density: 1.5±0.1 g/cm3
  • Boiling Point: 373.2±32.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 152.9±23.6 °C
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Boc-NH-PEG8-CH2CH2NH2

Boc-NH-PEG8-CH2CH2NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1052207-59-6
  • MF: C23H48N2O10
  • MW: 512.63
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Benzyl-PEG9-THP

Benzyl-PEG9-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 669556-53-0
  • MF: C30H52O11
  • MW: 588.72700
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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m-PEG4-CH2-aldehyde

m-PEG4-CH2-aldehyde is a PEG-based based PROTAC linker can be used in the synthesis of PROTACs.

  • CAS Number: 1059189-65-9
  • MF: C11H22O6
  • MW: 250.29
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Pyrene-PEG5-propargyl

Pyrene-PEG5-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1817735-33-3
  • MF: C30H33NO6
  • MW: 503.59
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Fmoc-Hyp(Bom)-OH

Fmoc-Hyp(Bom)-OH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-Hyp(Bom)-OH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]<

  • CAS Number: 187223-15-0
  • MF: C28H33N3O8
  • MW: 539.577
  • Catalog: ADC Linker
  • Density: 1.35±0.1 g/cm3
  • Boiling Point: 749.0±60.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 406.8±32.9 °C
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Boc-NH-PEG4-C3-acid

Boc-N-amido-PEG4-C3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1416777-48-4
  • MF: C17H33NO8
  • MW: 379.446
  • Catalog: PROTAC Linker
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 515.5±50.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 265.6±30.1 °C
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N-(Azido-PEG3)-N-bis(PEG3-Boc)

N-(Azido-PEG3)-N-bis(PEG3-Boc) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2055042-56-1
  • MF: C34H66N4O13
  • MW: 738.91
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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m-PEG8-(CH2)12-phosphonic acid ethyl ester

m-PEG8-(CH2)12-phosphonic acid ethyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2112737-70-7
  • MF: C31H65O11P
  • MW: 644.81
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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t-butyoxycarboxy-PEG4-phosphonic acid ethyl ester

Boc-PEG4-phosphonic acid ethyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1623791-77-4
  • MF: C19H39O9P
  • MW: 442.48
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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1-Hydroxy-3,6,9,12,15,18,21,24,27,30-decaoxatritriacontan-33-oic acid

Hydroxy-PEG10-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2375611-66-6
  • MF: C23H46O13
  • MW: 530.60
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Br-PEG6-CH2COOtBu

Br-PEG6-CH2COOtBu is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 297162-48-2
  • MF: C18H35BrO8
  • MW: 459.37
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Dde Biotin-PEG4-TAMRA-PEG4 Alkyne

Dde Biotin-PEG4-TAMRA-PEG4 Alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2353409-55-7
  • MF: C72H101N9O18S
  • MW: 1412.69
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Propargyl-PEG6-alcohol

Propargyl-PEG6-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

  • CAS Number: 944560-99-0
  • MF: C15H28O7
  • MW: 320.379
  • Catalog: PROTAC Linker
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 408.8±40.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 201.1±27.3 °C
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Amine-PEG3-Desthiobiotin

Amine-PEG3-Desthiobiotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2237234-71-6
  • MF: C18H36N4O5
  • MW: 388.50
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Biotin-PEG3-alcohol

Biotin-PEG3-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTAC.

  • CAS Number: 289714-02-9
  • MF: C16H29N3O5S
  • MW: 375.48
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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