Boc-NH-PEG4-C3-acid

Modify Date: 2024-01-10 07:58:29

Boc-NH-PEG4-C3-acid Structure
Boc-NH-PEG4-C3-acid structure
Common Name Boc-NH-PEG4-C3-acid
CAS Number 1416777-48-4 Molecular Weight 379.446
Density 1.1±0.1 g/cm3 Boiling Point 515.5±50.0 °C at 760 mmHg
Molecular Formula C17H33NO8 Melting Point N/A
MSDS N/A Flash Point 265.6±30.1 °C

 Use of Boc-NH-PEG4-C3-acid


Boc-N-amido-PEG4-C3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name t-Boc-N-amido-PEG4-(CH2)3CO2H
Synonym More Synonyms

 Boc-NH-PEG4-C3-acid Biological Activity

Description Boc-N-amido-PEG4-C3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 515.5±50.0 °C at 760 mmHg
Molecular Formula C17H33NO8
Molecular Weight 379.446
Flash Point 265.6±30.1 °C
Exact Mass 379.220612
LogP 0.07
Vapour Pressure 0.0±2.9 mmHg at 25°C
Index of Refraction 1.466

 Synonyms

BOC-N-AMIDO-PEG4-(CH2)3CO2H
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