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Boc-NH-PEG4-C3-acid

Names

[ CAS No. ]:
1416777-48-4

[ Name ]:
Boc-NH-PEG4-C3-acid

[Synonym ]:
BOC-N-AMIDO-PEG4-(CH2)3CO2H

Biological Activity

[Description]:

Boc-N-amido-PEG4-C3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
515.5±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C17H33NO8

[ Molecular Weight ]:
379.446

[ Flash Point ]:
265.6±30.1 °C

[ Exact Mass ]:
379.220612

[ LogP ]:
0.07

[ Vapour Pressure ]:
0.0±2.9 mmHg at 25°C

[ Index of Refraction ]:
1.466

Related Compounds