Boc-NH-PEG4-CH2CH2NH2

Names

[ CAS No. ]:
811442-84-9

[ Name ]:
Boc-NH-PEG4-CH2CH2NH2

[Synonym ]:
tert-butyl N-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethyl]carbamate

Biological Activity

[Description]:

Boc-NH-PEG4-CH2CH2NH2 a cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

Cleavable

[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

[References]

[1]. Hans-Georg Lerchen, et al. Preparation of antibody drug conjugates of kinesin spindle protein (KSP) inhibitors with anti-TWEAKR-antibodies. WO2016207094A1.

Chemical & Physical Properties

[ Density]:
1.059

[ Molecular Formula ]:
C₁₅H₃₂N₂O₆

[ Molecular Weight ]:
336.42400

[ Flash Point ]:
222 °C

[ Exact Mass ]:
336.22600

[ PSA ]:
101.27000

[ LogP ]:
1.62740

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2924199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924199090

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%