Amino-PEG4-C2-amine

Names

[ CAS No. ]:
68960-97-4

[ Name ]:
Amino-PEG4-C2-amine

[Synonym ]:
1,14-diamino-3,6,9,12-tetraoxatetradecane
3,6,9,12-Tetraoxatetradecane-1,14-diamine

Biological Activity

[Description]:

Amino-PEG4-C2-amine is a PEG-based (4 units) PROTAC linker can be used in the synthesis of PROTACs.

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Lepage ML, et al. Design, synthesis and photochemical properties of the first examples of iminosugar clustersbased on fluorescent cores. Beilstein J Org Chem. 2015 May 6;11:659-67.

Chemical & Physical Properties

[ Boiling Point ]:
139 °C/0.2 mmHg

[ Molecular Formula ]:
C₁₀H₂₄N₂O₄

[ Molecular Weight ]:
236.30900

[ Flash Point ]:
157 °C

[ Exact Mass ]:
236.17400

[ PSA ]:
88.96000

[ LogP ]:
0.37080

[ Index of Refraction ]:
1.47

Safety Information

[ Hazard Class ]:
8.0

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.