Azido-PEG2-C2-amine

Names

[ Name ]:
Azido-PEG2-C2-amine

[Synonym ]:
2-(2-(2-azidoethoxy)exthoxy)ethanamine
1-AMINO-8-AZIDO-3,5-DIOXAOCTANE
Amino-PEG2-Azide
2-azidoethyloxyethyloxyethylamine
2-(2-(2-azidoethoxy)ethoxy)ethanamine
1-(2-AMINOETHOXY)-2-(2-AZIDOETHOXY)ETHANE
2-[2-(2-azidoethoxy)-ethoxy]-ethylamine

Biological Activity

[Description]:

Azido-PEG2-C2-amine (N3-PEG2-CH2CH2NH2) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG2-C2-amine is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Non-cleavable

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].

[References]

[1]. Su S, et al. Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 22;62(16):7575-7582.

[2]. Tominari, Yusuk , et al. Heterocyclic compound. WO2020027225A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C₆H₁₄N₄O₂

[ Molecular Weight ]:
174.20100

[ Exact Mass ]:
174.11200

[ PSA ]:
94.23000

[ LogP ]:
0.44166

[ Storage condition ]:
2-8°C

Azido-PEG2-C2-amine

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds