Azido-PEG2-C2-Boc

Names

[ Name ]:
Azido-PEG2-C2-Boc

[Synonym ]:
Propanoic acid, 3-[2-(2-azidoethoxy)ethoxy]-, 1,1-dimethylethyl ester
2-Methyl-2-propanyl 3-[2-(2-azidoethoxy)ethoxy]propanoate

Biological Activity

[Description]:

Azido-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₁H₂₁N₃O₄

[ Molecular Weight ]:
259.302

[ Exact Mass ]:
259.153198

[ LogP ]:
1.34

Azido-PEG2-C2-Boc

Names

Biological Activity

Chemical & Physical Properties

Related Compounds