N-BOC-2,2′-(ethylenedioxy)bis(ethylamine)

Names

[ Name ]:
N-BOC-2,2′-(ethylenedioxy)bis(ethylamine)

[Synonym ]:
CBZ-L-Asginine-OH Hydrochloride
AmbotzBNN1016
2-Methyl-2-propanyl {2-[2-(2-aminoethoxy)ethoxy]ethyl}carbamate
N-BOC-2,2′-(ethylenedioxy)bis(ethylamine)
Carbamic acid, N-[2-[2-(2-aminoethoxy)ethoxy]ethyl]-, 1,1-dimethylethyl ester
N-Boc-3,6-dioxa-1,8-octanediamine
N-Boc-3,6-dioxaoctane-1,8-diamine
t-Boc-N-amido-PEG2-Amine

Biological Activity

[Description]:

PROTAC Linker 13 is a PROTAC linker, which refers to the alkyl/ether composition. PROTAC Linker 13 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl/ether

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
365.2±27.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₁H₂₄N₂O₄

[ Molecular Weight ]:
248.319

[ Flash Point ]:
174.6±23.7 °C

[ Exact Mass ]:
248.173615

[ PSA ]:
82.81000

[ LogP ]:
0.19

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.460

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

A modular cross-linking approach for exploring protein interactions.

J. Am. Chem. Soc. 125 , 2416 - 2425, (2003)

A method is described for the elucidation of protein-protein interactions using novel cross-linking reagents and mass spectrometry. The method incorporates (1) a modular solid-phase synthetic strategy...

Spinke, J., et al.

J. Phys. Chem. 99(9) , 7012-7019, (1993)

Sigal, G. B., et al.

J. Am. Chem. Soc. 118 , 3789-3800, (1996)