Mal-PEG2-NH2 TFA

Names

[ Name ]:
Mal-PEG2-NH2 TFA

[Synonym ]:
O-(2-Aminoethyl)-O inverted exclamation marka-(2-maleimidoethyl)ethylene glycol trifluoroacetate salt
O-(2-aminoethyl)-O'-(2-maleimidoethyl)ethylene glycol trifluoroacetate salt
1-[2-[2-(2-Aminoethoxy)ethoxy]ethyl]-1H-pyrrole-2,5-dione trifluoroacetate salt

Biological Activity

[Description]:

Mal-PEG2-NH2 (TFA) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₂H₁₇F₃N₂O₆

[ Molecular Weight ]:
342.26800

[ Exact Mass ]:
342.10400

[ PSA ]:
119.16000

[ LogP ]:
0.17480

Mal-PEG2-NH2 TFA

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds