ethylene glycol bis(2-aminoethyl) ether

Names

[ CAS No. ]:
929-59-9

[ Name ]:
ethylene glycol bis(2-aminoethyl) ether

[Synonym ]:
2,2′-(ethylenedioxy)bis(ethylamine)
1,8-diaminotriethyleneglycol
MFCD00040474
2,2'-[1,2-Ethanediylbis(oxy)]diethanamine
2,2'-[ethane-1,2-diylbis(oxy)]diethanamine
1,2-Bis(2-aminoethoxy)ethane
UNII-R41ZT4UF34
Jeffamine® EDR-176
EDR-148
TRIETHYLENEGLYCOLDIAMINE
1,8-Diamino-3,6-dioxaoctane
DA-10
Jeffamine(R) EDR-176
2,2'-(Ethylenedioxy)bis(ethylamine)
1,8-diamino-3,6-dioxa-octane
3,6-dioxaoctamethylenediamine
Ethanamine, 2,2'-(1,2-ethanediylbis(oxy))bis-
3,6-dioxa-1,8-octanediamine
EINECS 213-203-6
Ethanamine, 2,2'-[1,2-ethanediylbis(oxy)]bis-
Jeffamine EDR-148

Biological Activity

[Description]:

PROTAC Linker 19 is a PROTAC linker, which refers to the alkyl/ether composition. PROTAC Linker 19 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl/ether

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
241.0±20.0 °C at 760 mmHg

[ Molecular Formula ]:
C₆H₁₆N₂O₂

[ Molecular Weight ]:
148.203

[ Flash Point ]:
104.3±15.5 °C

[ Exact Mass ]:
148.121185

[ PSA ]:
70.50000

[ LogP ]:
-1.59

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.460

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS05, GHS07, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H314-H317-H334

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
C:Corrosive;

[ Risk Phrases ]:
R22;R34;R42/43

[ Safety Phrases ]:
S23-S26-S36/37/39-S45

[ RIDADR ]:
UN 2735 8/PG 2

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ Hazard Class ]:
8

[ HS Code ]:
2922199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922199090

[ Summary ]:
2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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