PROTAC Linker

Total: 1884
Updated: 2019-06-28 15:55:20
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.

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Neuronal Signaling >
5-HT Receptor AChE Adenosine Kinase Amyloid-β Beta-secretase CaMK CGRP Receptor COMT Dopamine Receptor Dopamine Transporter FAAH GABA Receptor GlyT iGluR Imidazoline Receptor mAChR Melatonin Receptor Monoamine Oxidase nAChR Neurokinin Receptor Opioid Receptor Serotonin Transporter γ-secretase
NF-κB >
NF-κB IKK Keap1-Nrf2 MALT1
PI3K/Akt/mTOR >
Akt AMPK ATM/ATR DNA-PK GSK-3 MELK mTOR PDK-1 PI3K PI4K PIKfyve PTEN
PROTAC >
PROTAC E3 Ligase Ligand-Linker Conjugate Ligand for E3 Ligase PROTAC Linker PROTAC-linker Conjugate for PAC
Protein Tyrosine Kinase/RTK >
Ack1 ALK Bcr-Abl BMX Kinase Btk c-Fms c-Kit c-Met/HGFR Discoidin Domain Receptor DYRK EGFR Ephrin Receptor FAK FGFR FLT3 IGF-1R Insulin Receptor IRAK Itk PDGFR PKA Pyk2 ROS Src Syk TAM Receptor Trk Receptor VEGFR
Stem Cell/Wnt >
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TGF-beta/Smad >
TGF-beta/Smad PKC ROCK TGF-β Receptor
Vitamin D Related >
VD/VDR
Others >
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N-(Azido-PEG3)-N-bis(PEG4-acid)

N-(Azido-PEG3)-N-bis(PEG4-acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2112731-54-9
  • MF: C30H58N4O15
  • MW: 714.80
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Azido-PEG4-Amido-tri-(t-butoxycarbonylethoxymethyl)-methane

Azido-PEG4-Amido-tri-(t-butoxycarbonylethoxymethyl)-methane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1421933-29-0
  • MF: C36H66N4O14
  • MW: 778.93
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Propargyl-PEG2-bromide

Propargyl-PEG2-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1287660-82-5
  • MF: C7H11BrO2
  • MW: 207.07
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Azido-PEG1-CH2CO2-t-Bu

Azido-PEG1-C1-Boc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1820717-35-8
  • MF: C8H15N3O3
  • MW: 201.22
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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1-(3-(Dimethylamino)propyl)-3-ethylurea 1-((3-(2-(2-(((cyclooct-4-en-1-yloxy)carbonyl)amino)ethoxy)ethoxy)propanoyl)oxy)-2,5-dioxopyrrolidine-3-sulfonate

TCO-PEG2-Sulfo-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2353409-48-8
  • MF: C28H49N5O12S
  • MW: 679.78
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Amino-PEG11-acid

Amino-PEG12-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1415408-69-3
  • MF: C27H55NO14
  • MW: 617.72
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Thiol-C9-PEG4

Thiol-C9-PEG4 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 130727-41-2
  • MF: C17H36O4S
  • MW: 336.53000
  • Catalog: PROTAC Linker
  • Density: 0.995 g/mL at 25ºC
  • Boiling Point: 446.5ºC at 760 mmHg
  • Melting Point: N/A
  • Flash Point: >110ºC
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t-Boc-aminooxy-PEG4-propargyl

Boc-aminooxy-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1895922-77-6
  • MF: C16H29NO7
  • MW: 347.40
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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t-Boc-N-amido-PEG2-NHS ester

Boc-NH-PEG2-C2-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2183440-73-3
  • MF: C16H26N2O8
  • MW: 374.39
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Boc-11-aminoundecanoic acid

Boc-11-aminoundecanoic acid is an Alkyl/ether-based PROTAC linker can be used in the synthesis of MS432 (HY-130602)[1].

  • CAS Number: 10436-25-6
  • MF: C16H31NO4
  • MW: 301.42200
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: 68 °C
  • Flash Point: N/A
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Br-PEG3-ethyl acetate

Br-PEG3-ethyl acetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 308085-31-6
  • MF: C10H19BrO5
  • MW: 299.16
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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m-PEG24-NHS ester

m-PEG24-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2395839-96-8
  • MF: C54H103NO28
  • MW: 1214.39
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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DBCO-S-S-PEG3-Biotin

DBCO-S-S-PEG3-biotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1430408-09-5
  • MF: C42H56N6O8S3
  • MW: 869.124
  • Catalog: PROTAC Linker
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: 1194.2±65.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 676.0±34.3 °C
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DBCO-PEG1-amine

DBCO-PEG1-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2364591-79-5
  • MF: C23H25N3O3
  • MW: 391.46
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Triethylene glycol bis(p-toluenesulfonate)

Triethylene glycol bis(p-toluenesulfonate) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 19249-03-7
  • MF: C20H26O8S2
  • MW: 458.546
  • Catalog: PROTAC Linker
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: 608.4±55.0 °C at 760 mmHg
  • Melting Point: 78-82 °C(lit.)
  • Flash Point: 321.7±31.5 °C
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mPEG16-Br

m-PEG16-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1238189-11-1
  • MF: C33H67BrO16
  • MW: 799.78
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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N-(Amino-PEG4)-N-Biotin-PEG4-acid

N-(Amino-PEG4)-N-Biotin-PEG4-acid is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2100306-84-9
  • MF: C31H58N4O12S
  • MW: 710.88
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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M-Peg3-sulfone-peg2-oh

m-PEG3-Sulfone-PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1919045-00-3
  • MF: C13H28O8S
  • MW: 344.42
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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NH2-C4-NH-Boc

NH2-C4-NH-Boc (compound 15) is a PROTAC linker, which refers to the Alkyl/ether composition. NH2-C4-NH-Boc can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

  • CAS Number: 68076-36-8
  • MF: C9H20N2O2
  • MW: 188.267
  • Catalog: PROTAC Linker
  • Density: 1.0±0.1 g/cm3
  • Boiling Point: 292.9±23.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 130.9±22.6 °C
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4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenol

4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenol is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 58884-35-8
  • MF: C9H8N4O
  • MW: 188.19
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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S-acetyl-PEG3-phosphonic acid ethyl ester

S-acetyl-PEG3-phosphonic acid ethyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2173125-29-4
  • MF: C14H29O7PS
  • MW: 372.41
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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PEG4-Ms

PEG4-Ms is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 65883-12-7
  • MF: C9H20O7S
  • MW: 272.31600
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Amino-PEG24-alcohol

Amino-PEG24-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2226726-55-0
  • MF: C48H99NO24
  • MW: 1074.29
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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NH-bis(m-PEG8)

NH-bis(m-PEG8) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2055013-64-2
  • MF: C34H71NO16
  • MW: 749.92
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Tos-PEG5-Boc

Tos-PEG5-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 581065-94-3
  • MF: C22H36O9S
  • MW: 476.58100
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Fmoc-amino-PEG5-acid

Fmoc-amino-PEG5-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 882847-32-7
  • MF: C28H37NO9
  • MW: 531.59500
  • Catalog: PROTAC Linker
  • Density: 1.210±0.06 g/cm3 (20ºC 760 Torr)
  • Boiling Point: 711.4±60.0°C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: N/A
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DNP-PEG3-azide

DNP-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 951671-87-7
  • MF: C14H20N6O7
  • MW: 384.34
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Boc-NH-PEG3-CH2COOH

Boc-NH-PEG3-CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC[1].

  • CAS Number: 462100-06-7
  • MF: C13H25NO7
  • MW: 307.34000
  • Catalog: PROTAC Linker
  • Density: 1.141±0.06 g/cm3
  • Boiling Point: 460.1±35.0°C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: N/A
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Tos-PEG2-C2-Boc

Tos-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 850090-13-0
  • MF: C18H28O7S
  • MW: 388.476
  • Catalog: PROTAC Linker
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 495.2±35.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 253.3±25.9 °C
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Azido-PEG4-t-Boc-hydrazide

Azido-PEG4-hydrazide-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1919045-01-4
  • MF: C16H31N5O7
  • MW: 405.45
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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