462100-06-7

462100-06-7 structure

Name: Boc-NH-PEG3-CH2COOH
Chemical Name: Boc-11-amino-3,6,9-trioxaundecanoic acid
CAS Number: 462100-06-7
Molecular Formula: C₁₃H₂₅NO₇
Molecular Weight: 307.34000
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-05-03 01:18:27
Modify Date: 2025-08-26 16:29:20
Boc-NH-PEG3-CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC[1].

Name	Boc-11-amino-3,6,9-trioxaundecanoic acid
Synonyms	Boc-NH-PEG3-COOH {2-[2-(2-tert-butoxycarbonylamino-ethoxy)-ethoxy]-ethoxy}-acetic acid 2-[2-{2-(N-tert-butoxycarbonyl)aminoethoxy}ethoxy]ethoxyacetic acid 2,2-dimethyl-4-oxo-3,8,11,14-tetraoxa-5-azohexadecan-16-oic acid 11-N-t-Boc-amino-3,6,9-trioxaundecanoic acid Boc-NH-mini-PEG-COOH 5,8,11-Trioxa-2-azatridecanedioic acid 1-(1,1-dimethylethyl) ester

Description	Boc-NH-PEG3-CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs Alkyl/ether
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References	[1]. Vollmer S, et al. Design, Synthesis, and Biological Evaluation of MEK PROTACs. J Med Chem. 2020 Jan 9;63(1):157-162.