PROTAC Linker

Total: 1884
Updated: 2019-06-28 15:55:20
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.

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PROTAC >
PROTAC E3 Ligase Ligand-Linker Conjugate Ligand for E3 Ligase PROTAC Linker PROTAC-linker Conjugate for PAC
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Hydroxy-PEG2-methyl ester

Hydroxy-PEG2-C2-methyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 457897-73-3
  • MF: C8H16O5
  • MW: 192.21
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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N-(azide-PEG3)-N'-(Mal-PEG4)-Cy5

N-(azide-PEG3)-N'-(Mal-PEG4)-Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2107273-74-3
  • MF: C50H68ClN7O10
  • MW: 962.57
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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NH2-PEG6-Boc

NH2-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. NH2-PEG6-Boc is also a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

  • CAS Number: 1286281-32-0
  • MF: C19H39NO8
  • MW: 409.51500
  • Catalog: ADC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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DNP-PEG4-NHS ester

DNP-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 858126-78-0
  • MF: C21H28N4O12
  • MW: 528.46700
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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m-PEG3-azide

m-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 74654-06-1
  • MF: C7H15N3O3
  • MW: 189.21200
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Propargyl-PEG9-amine

Propargyl-PEG9-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

  • CAS Number: 2093153-98-9
  • MF: C21H41NO9
  • MW: 451.55
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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H2n-peg13-ch2ch2nh2

Amino-PEG13-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1228119-65-0
  • MF: C28H60N2O13
  • MW: 632.78
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Thiol-C10-amide-PEG8

Thiol-C10-amide-PEG8 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1353948-95-4
  • MF: C27H55NO9S
  • MW: 569.79
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Biotin-C1-PEG3-C3-amine TFA

Biotin-C1-PEG3-C3-amine (TFA) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1334172-59-6
  • MF: C22H39F3N4O7S
  • MW: 560.63
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Mal-PEG2-oxyamine

Mal-PEG2-oxyamine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1146245-73-9
  • MF: C10H16N2O5
  • MW: 244.24
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Tetraethyl heptane-1,7-diylbis(phosphonate)

Tetraethyl heptane-1,7-diylbis(phosphonate) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 5943-17-9
  • MF: C15H34O6P2
  • MW: 332.35100
  • Catalog: PROTAC Linker
  • Density: 1.202g/cm3
  • Boiling Point: 494.4ºC at 760mmHg
  • Melting Point: N/A
  • Flash Point: 252.8ºC
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Propargyl-PEG6-thiol

Propargyl-PEG6-SH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1422540-91-7
  • MF: C15H28O6S
  • MW: 336.44
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Propargyl-PEG12-OH

Propargyl-PEG12-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

  • CAS Number: 1036204-61-1
  • MF: C27H52O13
  • MW: 584.694
  • Catalog: PROTAC Linker
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 613.0±50.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 324.5±30.1 °C
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Bis-aminooxy-PEG7

Bis-aminooxy-PEG7 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1383980-52-6
  • MF: C16H36N2O9
  • MW: 400.47
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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DBCO-C2-alcohol

DBCO-PEG1 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1839049-33-0
  • MF: C21H20N2O3
  • MW: 348.40
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Pomalidomide-PEG4-azide

Pomalidomide-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2271036-47-4
  • MF: C23H30N6O8
  • MW: 518.52
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Ald-CH2-PEG10-Boc

Ald-CH2-PEG10-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2353410-05-4
  • MF: C27H52O13
  • MW: 584.69
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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t-Boc-Aminooxy-PEG7-methane

t-Boc-Aminooxy-PEG7-methane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2055041-27-3
  • MF: C20H41NO10
  • MW: 455.54
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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CH2COOH-PEG3-CH2COOH

CH2COOH-PEG3-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 32775-08-9
  • MF: C10H18O8
  • MW: 266.24500
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Tetrazine-NHS ester

Tetrazine-Ph-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1616668-55-3
  • MF: C14H11N5O4
  • MW: 313.27
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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m-PEG8-thiol

m-PEG8-thiol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 651042-83-0
  • MF: C17H36O8S
  • MW: 400.52800
  • Catalog: PROTAC Linker
  • Density: 1.07
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Butane-1,4-diyldiphosphonic acid

Butane-1,4-diyldiphosphonic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 4671-77-6
  • MF: C4H12O6P2
  • MW: 218.08200
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: 544.4ºC at 760 mmHg
  • Melting Point: 219-221ºC
  • Flash Point: 283.1ºC
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Azido-PEG2-propargyl

Azido-PEG2-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1245006-63-6
  • MF: C7H11N3O2
  • MW: 169.18
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Biotin-peg6-t-butylester

Biotin-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1352814-07-3
  • MF: C29H53N3O10S
  • MW: 635.81
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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N-(m-PEG4)-N'-(amino-PEG3)-Cy5

N-(m-PEG4)-N'-(amino-PEG3)-Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2107272-96-6
  • MF: C42H62ClN3O7
  • MW: 756.41
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Benzyl-PEG2-CH2-Boc

Benzyl-PEG2-CH2-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

  • CAS Number: 1643957-26-9
  • MF: C17H26O5
  • MW: 310.385
  • Catalog: PROTAC Linker
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 396.0±27.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 170.7±23.8 °C
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m-PEG7-alcohol

m-PEG7-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 4437-01-8
  • MF: C15H32O8
  • MW: 340.410
  • Catalog: PROTAC Linker
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 416.0±40.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 205.4±27.3 °C
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3-(2-Pyridyldithio)propanoic Acid

3-(2-Pyridyldithio)propanoic Acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 68617-64-1
  • MF: C8H9NO2S2
  • MW: 215.29300
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: 68-71C
  • Flash Point: N/A
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2-{2-[2-(Benzyloxy)ethoxy]ethoxy}ethanol

Triethylene glycol monobenzyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 55489-58-2
  • MF: C13H20O4
  • MW: 240.296
  • Catalog: PROTAC Linker
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 358.0±27.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 170.3±23.7 °C
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Acid-PEG7-t-butyl ester

Acid-PEG7-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2134235-86-0
  • MF: C22H42O11
  • MW: 482.56
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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