74654-06-1
74654-06-1 structure
- Name: m-PEG3-azide
- Chemical Name: 1-azido-2-[2-(2-methoxyethoxy)ethoxy]ethane
- CAS Number: 74654-06-1
- Molecular Formula: C7H15N3O3
- Molecular Weight: 189.21200
- Catalog: Signaling Pathways PROTAC PROTAC Linker
- Create Date: 2017-09-05 14:51:41
- Modify Date: 2024-01-09 11:41:49
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m-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
| Name | 1-azido-2-[2-(2-methoxyethoxy)ethoxy]ethane |
|---|---|
| Synonyms |
1-azido-triethylene glycol monomethyl ether
azidotriethylene glycol methyl ether triethyleneglycol monomethyl ether azide AmbotzPEG1219 1-Azido-3,6,9-trioxodecane |
| Description | m-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
|---|---|
| Related Catalog | |
| Target |
PEGs |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
| Molecular Formula | C7H15N3O3 |
|---|---|
| Molecular Weight | 189.21200 |
| Exact Mass | 189.11100 |
| PSA | 77.44000 |
| LogP | 0.42906 |
|
~95%
74654-06-1 |
| Literature: Dan, Krishna; Bose, Nivedita; Ghosh, Suhrit Chemical Communications, 2011 , vol. 47, # 46 p. 12491 - 12493 |
|
~90%
74654-06-1 |
| Literature: Brouwer, Arwin J.; Mulders, Suzanne J. E.; Liskamp, Rob M. J. European Journal of Organic Chemistry, 2001 , # 10 p. 1903 - 1915 |
|
~97%
74654-06-1 |
| Literature: Nulwala, Hunaid B.; Tang, Chau N.; Kail, Brian W.; Damodaran, Krishnan; Kaur, Palwinder; Wickramanayake, Shan; Shi, Wei; Luebke, David R. Green Chemistry, 2011 , vol. 13, # 12 p. 3345 - 3349 |
|
~%
74654-06-1 |
| Literature: Loubinoux, B; Colin, JL; Thomas, V European Journal of Medicinal Chemistry, 1991 , vol. 26, # 4 p. 461 - 467 |
| Precursor 4 | |
|---|---|
| DownStream 1 | |
