Propargyl-PEG12-OH

Modify Date: 2024-01-22 21:21:10

Propargyl-PEG12-OH Structure
Propargyl-PEG12-OH structure
Common Name Propargyl-PEG12-OH
CAS Number 1036204-61-1 Molecular Weight 584.694
Density 1.1±0.1 g/cm3 Boiling Point 613.0±50.0 °C at 760 mmHg
Molecular Formula C27H52O13 Melting Point N/A
MSDS N/A Flash Point 324.5±30.1 °C

 Use of Propargyl-PEG12-OH


Propargyl-PEG12-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

 Names

Name Propargyl-PEG13-alcohol
Synonym More Synonyms

 Propargyl-PEG12-OH Biological Activity

Description Propargyl-PEG12-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References

[1]. Sandanaraj BS, et al. Rational Design of Supramolecular Dynamic Protein Assemblies by Using a Micelle-AssistedActivity-Based Protein-Labeling Technology. Chemistry. 2018 Oct 26;24(60):16085-16096.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 613.0±50.0 °C at 760 mmHg
Molecular Formula C27H52O13
Molecular Weight 584.694
Flash Point 324.5±30.1 °C
Exact Mass 584.340820
LogP -4.19
Vapour Pressure 0.0±4.0 mmHg at 25°C
Index of Refraction 1.467
Storage condition 2-8°C

 Synonyms

3,6,9,12,15,18,21,24,27,30,33,36-Dodecaoxanonatriacont-38-yn-1-ol
MFCD28334508