Propargyl-PEG12-OH

Names

[ CAS No. ]:
1036204-61-1

[ Name ]:
Propargyl-PEG12-OH

[Synonym ]:
3,6,9,12,15,18,21,24,27,30,33,36-Dodecaoxanonatriacont-38-yn-1-ol
MFCD28334508

Biological Activity

[Description]:

Propargyl-PEG12-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Sandanaraj BS, et al. Rational Design of Supramolecular Dynamic Protein Assemblies by Using a Micelle-AssistedActivity-Based Protein-Labeling Technology. Chemistry. 2018 Oct 26;24(60):16085-16096.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
613.0±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₇H₅₂O₁₃

[ Molecular Weight ]:
584.694

[ Flash Point ]:
324.5±30.1 °C

[ Exact Mass ]:
584.340820

[ LogP ]:
-4.19

[ Vapour Pressure ]:
0.0±4.0 mmHg at 25°C

[ Index of Refraction ]:
1.467

[ Storage condition ]:
2-8°C

Propargyl-PEG12-OH

Names

Biological Activity

Chemical & Physical Properties

Related Compounds