m-PEG12-OH

Names

[ CAS No. ]:
2050595-03-2

[ Name ]:
m-PEG12-OH

Biological Activity

[Description]:

m-PEG12-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. m-PEG12-OH is also a non-cleavable 12 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Non-cleavable

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].

[References]

[1]. Kachbi-Khelfallah S, et al. Towards potential nanoparticle contrast agents: Synthesis of new functionalized PEG bisphosphonates. Beilstein J Org Chem. 2016 Jul 4;12:1366-71.

[2]. Hamura, Mika, et al. Branched monodispersed polyethylene glycol, intermediate, and method for producing same. WO 2019181984 A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅H₅₂O₁₃

[ Molecular Weight ]:
560.67

[ Storage condition ]:
-20°C

Related Compounds

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