Propargyl-PEG3-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
N-(Azido-PEG2)-N-Boc-PEG3-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
CC-3060 is a Cereblon modulator that promotes ZBTB16 degradation. CC-3060 degrades ZBTB16 with a DC50 of 0.47 nM in HT-1080 cells. CC-3060 targets ZBTB16 for degradation by primarily engaging distinct structural degrons on different zinc finger domains[1].
Azido-PEG3-Sulfone-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
E3 ligase Ligand-Linker Conjugates 34 incorporates a cIAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. E3 ligase Ligand-Linker Conjugates 34 can be used to design PROTAC degrader[1].
dBRD4-BD1 is a selective and durable BRD4 degrader with an DC50 value of 280 nM (Dmax=77%). dBRD4-BD1 upregulates BRD2/3 protein level and shows low cytotoxicity than iBRD4-BD1[1].
DBCO-PEG3-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Methylamino-PEG1-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
DBCO-PEG9-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Azido-PEG3-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
2-Azido-PEG3-amido-13-biscarboxylethoxypropane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
An E3 ligase ligand-linker conjugate for PROTAC.
APN-C3-PEG4-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
VH032-C4-NH-Boc is a Boc-modified VH032 (HY-120217) that acts as a ligand for VHL to recruit von Hippel-Lindau (VHL) proteins. VH032-C4-NH-Boc will remove the protecting group under acidic conditions and be directly used in PROTAC molecule synthesis. VH032-C4-NH-Boc is a key intermediate in the synthesis of PROTAC based on VHL ligand.
DA-PROTAC is a potent PROTAC degrader of copper ion-transport proteins Atox1 and CCS. DA-PROTAC can bind both Atox1 and CCS proteins, and the complex can be bound to E3 ligase, leading to increased levels of ubiquitination of Atox1 and CCS and degradation of Atox1 and CCS proteins via the proteasome pathway. DA-PROTAC can be used for triple negative breast cancer research[1].
Tos-PEG2-O-Propargyl is a PEG-based PROTAC linker can be used in the synthesis of Thalidomide-O-PEG2-propargyl (HY-126458)[1].
An E3 ligase ligand-linker conjugate for PROTAC.
OTs-C6-OBn is a PROTAC linker, which refers to the alkyl chain composition. OTs-C6-OBn can be used in the synthesis of PROTAC SGK3 degrader-1 (HY-125878)[1].
N-Boc-N-bis(PEG4-NHS ester) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Propargyl-PEG4-Sulfone-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Azido-PEG1-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
m-PEG9-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
NH2-PEG1-C1-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
m-PEG16-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
N-(PEG3-acid)-N-bis(PEG3-amine) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Tos-PEG2-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
DBCO-PEG6-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
N-(Propargyl-PEG4)-N-bis(PEG4-acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
N-(m-PEG4)-N'-hydroxypropyl-Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Thalidomide-5,6-F is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5,6-F can be connected to the ligand for protein by a linker to form PROTACs[1].