1119249-30-7
1119249-30-7 structure
- Name: Tos-PEG2-O-Propargyl
- Chemical Name: 2-[2-(prop-2-yn-1-yloxy)ethoxy]ethyl 4-methylbenzenesulfonate
- CAS Number: 1119249-30-7
- Molecular Formula: C14H18O5S
- Molecular Weight: 298.35500
- Catalog: Signaling Pathways PROTAC PROTAC Linker
- Create Date: 2018-03-24 04:25:23
- Modify Date: 2025-09-28 15:02:58
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Tos-PEG2-O-Propargyl is a PEG-based PROTAC linker can be used in the synthesis of Thalidomide-O-PEG2-propargyl (HY-126458)[1].
| Name | 2-[2-(prop-2-yn-1-yloxy)ethoxy]ethyl 4-methylbenzenesulfonate |
|---|---|
| Synonyms |
2-(2-(prop-2-ynyloxy)ethoxy)ethyl 4-methylbenzenesulfonate
3,6-dioxanon-8-yn-1-yl p-toluenesulfonate 1-O-tosyl-3,6-dioxanon-8-yne |
| Description | Tos-PEG2-O-Propargyl is a PEG-based PROTAC linker can be used in the synthesis of Thalidomide-O-PEG2-propargyl (HY-126458)[1]. |
|---|---|
| Related Catalog | |
| Target |
PEGs |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
| Molecular Formula | C14H18O5S |
|---|---|
| Molecular Weight | 298.35500 |
| Exact Mass | 298.08700 |
| PSA | 70.21000 |
| LogP | 2.44750 |
| Hazard Codes | Xi |
|---|