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444288-86-2

444288-86-2 structure
444288-86-2 structure
  • Name: Cc-3060
  • Chemical Name: CC-3060
  • CAS Number: 444288-86-2
  • Molecular Formula: C22H17N3O5
  • Molecular Weight: 403.39
  • Catalog: Signaling Pathways PROTAC Ligand for E3 Ligase
  • Create Date: 2024-09-16 14:05:09
  • Modify Date: 2024-09-16 14:05:09
  • CC-3060 is a Cereblon modulator that promotes ZBTB16 degradation. CC-3060 degrades ZBTB16 with a DC50 of 0.47 nM in HT-1080 cells. CC-3060 targets ZBTB16 for degradation by primarily engaging distinct structural degrons on different zinc finger domains[1].

Name CC-3060
Description CC-3060 is a Cereblon modulator that promotes ZBTB16 degradation. CC-3060 degrades ZBTB16 with a DC50 of 0.47 nM in HT-1080 cells. CC-3060 targets ZBTB16 for degradation by primarily engaging distinct structural degrons on different zinc finger domains[1].
Related Catalog
Target

DC50: 0.47 nM (ZBTB16 in HT-1080 cells)[1]

References

[1]. Matyskiela ME, et al. Cereblon Modulators Target ZBTB16 and Its Oncogenic Fusion Partners for Degradation via Distinct Structural Degrons. ACS Chem Biol. 2020 Dec 18;15(12):3149-3158.

Molecular Formula C22H17N3O5
Molecular Weight 403.39