Methyltetrazine-Sulfo-NHS ester (sodium) is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
(S,R,S)-AHPC-C10-NHBoc is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC (HY-125845) based VHL ligand and a linker used for BET-Targeted PROTAC[1].
Fluorescein-thiourea-PEG4-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
AZD-CO-C2-Ph-amido-Ph-azide is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Biotin-PEG3-Mal is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
E3 ligase Ligand-Linker Conjugates 8 is a synthesized compound that incorporates an E3 ligase ligand and a linker used in PROTAC technology.
Dde Biotin-PEG4-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Diketone-PEG4-Biotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
4-(N-Boc-amino)-1,6-heptanedioic acid is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Mal-PEG5-NHS ester is an Alkyl/ether and PEG-based PROTAC linker can be used in the synthesis of PROTACs.
PROTAC Linker 6 is a PROTAC linker, which refers to the alkyl/ether composition. PROTAC Linker 6 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
Biotin-PEG8-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
1,3-Bis-aminooxy propane is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Thalidomide-O-amido-PEG3-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology[1].
Boc-PEG8-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
NH-bis(PEG3-azide) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
6-Maleimidocaproic acid-PFP ester is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Diketone-PEG4-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTAC BRAF-V600E degrader-1 is a potent PROTAC BRAF-V600E degrader with Kd value of 2.4 nM and 2 nM for BRAF and BRAF-V600E, respectively. PROTAC BRAF-V600E degrader-1 degrades BRAF-V600E via the ubiquitin-proteasome system (UPS). PROTAC BRAF-V600E degrader-1 can inhibit melanoma cell growth[1].
Azido-PEG5-PFP ester is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs[1].
Diethyl 12-bromododecylphosphonate is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Amino-PEG3-C2-Azido is a PEG-based PROTAC linker can be used in the synthesis of the PARP1 degrader iRucaparib-TP3 (HY-130645)[1].
m-PEG5-phosphonic acid ethyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
N-Boc-N-bis(PEG3-azide) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
N-methyl-N'-methyl-O-(m-PEG4)-O'-(azide-PEG4)-Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Thalidomide-NH-C8-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].
N-(Aminooxy-PEG3)-N-bis(PEG4-Boc) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Biotin-PEG-Biotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
E3 ligase Ligand-Linker Conjugates 37 incorporates a cIAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. E3 ligase Ligand-Linker Conjugates 37 can be used to design PROTAC degrader[1].
Hydroxy-PEG4-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].