264231-28-9

264231-28-9 structure

Name: Diethyl 12-bromododecylphosphonate
Chemical Name: diethyl (12-bromododecyl)phosphonate
CAS Number: 264231-28-9
Molecular Formula: C₁₆H₃₄BrO₃P
Molecular Weight: 385.31700
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-04-29 21:52:42
Modify Date: 2024-01-09 15:41:00
Diethyl 12-bromododecylphosphonate is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	diethyl (12-bromododecyl)phosphonate
Synonyms	diethyl 12-bromododecylphosphonate BDPE

Description	Diethyl 12-bromododecylphosphonate is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Alkyl-Chain
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562