Amino-PEG3-C2-Azido structure
|
Common Name | Amino-PEG3-C2-Azido | ||
|---|---|---|---|---|
| CAS Number | 134179-38-7 | Molecular Weight | 218.25400 | |
| Density | 1.1 | Boiling Point | 198-202ºC | |
| Molecular Formula | C8H18N4O3 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS05 |
Signal Word | Danger | |
Use of Amino-PEG3-C2-AzidoAmino-PEG3-C2-Azido is a PEG-based PROTAC linker can be used in the synthesis of the PARP1 degrader iRucaparib-TP3 (HY-130645)[1]. |
| Name | 11-Azido-3,6,9-trioxaundecan-1-amine |
|---|---|
| Synonym | More Synonyms |
| Description | Amino-PEG3-C2-Azido is a PEG-based PROTAC linker can be used in the synthesis of the PARP1 degrader iRucaparib-TP3 (HY-130645)[1]. |
|---|---|
| Related Catalog | |
| In Vitro | Pomalidomide (a CRBN ligand and a known immunomodulatory imide drug (IMiD)) is conjugated to Rucaparib through a tri(ethylene glycol) (PEG3) linker to afford a compound that we designate as iRucaparib-TP3 (IMiD-Rucaparib with a triazole-PEG3 linker). iRucaparib-TP3 induces PARP1 degradation[1]. |
| References |
| Density | 1.1 |
|---|---|
| Boiling Point | 198-202ºC |
| Molecular Formula | C8H18N4O3 |
| Molecular Weight | 218.25400 |
| Exact Mass | 218.13800 |
| PSA | 103.46000 |
| LogP | 0.45826 |
| Index of Refraction | 1.47 |
| Storage condition | Amber Vial, Refrigerator, Under Inert Atmosphere |
| Symbol |
GHS05 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H314 |
| Precautionary Statements | P280-P305 + P351 + P338-P310 |
| Personal Protective Equipment | Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter |
| Hazard Codes | C,Xi |
| Risk Phrases | R34 |
| Safety Phrases | S26-S36/37/39-S45 |
| RIDADR | UN 2735 |
| WGK Germany | 3 |
| Packaging Group | III |
| HS Code | 2929909090 |
| Precursor 7 | |
|---|---|
| DownStream 3 | |
| HS Code | 2929909090 |
|---|---|
| Summary | 2929909090 other compounds with other nitrogen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |
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| Azido-PEG3-Amine |
| Amino-PEG3-Azide |
| 2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethanamine |
| 1-Amino-11-azido-3,6,9-trioxaundecane |
| 11-Amino-3,6,9-trioxaundecanyl Azide |