Amino-PEG3-C2-Azido

Names

[ Name ]:
Amino-PEG3-C2-Azido

[Synonym ]:
Azido-PEG3-Amine
Amino-PEG3-Azide
2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethanamine
1-Amino-11-azido-3,6,9-trioxaundecane
11-Amino-3,6,9-trioxaundecanyl Azide

Biological Activity

[Description]:

Amino-PEG3-C2-Azido is a PEG-based PROTAC linker can be used in the synthesis of the PARP1 degrader iRucaparib-TP3 (HY-130645)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[In Vitro]

Pomalidomide (a CRBN ligand and a known immunomodulatory imide drug (IMiD)) is conjugated to Rucaparib through a tri(ethylene glycol) (PEG3) linker to afford a compound that we designate as iRucaparib-TP3 (IMiD-Rucaparib with a triazole-PEG3 linker). iRucaparib-TP3 induces PARP1 degradation[1].

[References]

[1]. Wang S, et al. Uncoupling of PARP1 trapping and inhibition using selective PARP1 degradation. Nat Chem Biol. 2019 Dec;15(12):1223-1231.

Chemical & Physical Properties

[ Density]:
1.1

[ Boiling Point ]:
198-202ºC

[ Molecular Formula ]:
C₈H₁₈N₄O₃

[ Molecular Weight ]:
218.25400

[ Exact Mass ]:
218.13800

[ PSA ]:
103.46000

[ LogP ]:
0.45826

[ Index of Refraction ]:
1.47

[ Storage condition ]:
Amber Vial, Refrigerator, Under Inert Atmosphere

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H314

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
C,Xi

[ Risk Phrases ]:
R34

[ Safety Phrases ]:
S26-S36/37/39-S45

[ RIDADR ]:
UN 2735

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ HS Code ]:
2929909090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2929909090

[ Summary ]:
2929909090 other compounds with other nitrogen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

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