PEG4-Ms

Names

[ Name ]:
PEG4-Ms

[Synonym ]:
3,6,9,12-Tetraoxa-2-thiatetradecan-14-ol,2,2-dioxide
2-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}ethyl methanesulfonate
11-[(methylsulfonyl)oxy]-3,6,9-trioxaundecanol

Biological Activity

[Description]:

PEG4-Ms is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C₉H₂₀O₇S

[ Molecular Weight ]:
272.31600

[ Exact Mass ]:
272.09300

[ PSA ]:
99.67000

[ LogP ]:
0.08550

PEG4-Ms

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds