2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]acetic acid

Names

[ Name ]:
2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]acetic acid

[Synonym ]:
Azido-PEG3-carboxylate
2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]acetic acid

Biological Activity

[Description]:

PROTAC Linker 14 is a PROTAC linker, which refers to the alkyl/ether composition. PROTAC Linker 14 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl/ether

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Molecular Formula ]:
C₈H₁₅N₃O₅

[ Molecular Weight ]:
233.22200

[ Exact Mass ]:
233.10100

[ PSA ]:
114.74000

[ Index of Refraction ]:
1.47

MSDS

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Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds

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