Azido-PEG3-azide

Names

[ CAS No. ]:
101187-39-7

[ Name ]:
Azido-PEG3-azide

[Synonym ]:
1-azido-2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethane

Biological Activity

[Description]:

Azido-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Density]:
1.1703g/mL

[ Boiling Point ]:
163-196°C

[ Molecular Formula ]:
C₈H₁₆N₆O₃

[ Molecular Weight ]:
244.25100

[ Exact Mass ]:
244.12800

[ PSA ]:
127.19000

[ LogP ]:
0.56232

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Novel analogs of antitumor agent calixarene 0118: Synthesis, cytotoxicity, click labeling with 2-[(18)F]fluoroethylazide, and in vivo evaluation.

Eur. J. Med. Chem. 89 , 279-95, (2014)

Calixarene 0118 is a potent anti-angiogenic agent that effectively inhibited tumor growth in preclinical studies, and is currently being evaluated in a phase I clinical trial. We have designed two clo...